Publications by authors named "Jaclyn McTague"
Article Synopsis
- We present an enhanced Bonferroni method for testing two main endpoints in clinical trials that uses a data-adaptive critical value, taking into account the sample correlation coefficient.
- This method applies to the Student's t-test for mean testing under normal distribution with unknown correlation and variances.
- Our results include a more precise estimation of the type-1 error rate compared to traditional methods and a comparison with other common multiple testing procedures.
Exact critical values for group sequential designs with small sample sizes.
J Biopharm Stat
July 2020
Group sequential clinical trial designs allow the sequential hypothesis testing as data is accumulated over time, while ensuring the control of type-1 error rate. These designs vary in how they split the overall type-1 error among analyses, but practically, all assume that: 1. The underlying data is normal or approximately so, and 2.
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