Publications by authors named "Jaclyn L MacMillan"
Article Synopsis
- Clostridium perfringens is a Gram-positive bacterium that causes necrotic enteritis (NE) in poultry by penetrating the protective mucus layer in the small intestine, which consists of mucins made of glycosylated proteins.
- The study focuses on the unique composition of avian O-linked glycans in mucins that are enriched in sulfated sugars and sialic acid, giving them a negative charge that helps prevent pathogen colonization, although it's unclear how C. perfringens bypasses this barrier.
- Through experiments, it was found that C. perfringens can use certain monosaccharides found in chicken mucus as carbon sources for growth, including Neu5Ac and
