Antipsychotic use and fracture risk: An evaluation of incidence at a Veterans Affairs medical center.

Introduction: Recent meta-analyses have found a correlation between schizophrenia and increased fracture risk with one contributing factor potentially being antipsychotic-induced hyperprolactinemia, which may accelerate bone turnover. The objective of this study is to evaluate fracture rates in patients on long-term antipsychotic therapy to see if screening for osteoporosis should be included with routine monitoring.

Methods: Patients exposed to antipsychotics for ≥3 months during a 10-year study period were included in this retrospective analysis.