Metabolic and proteomic indications of diabetes progression in human aqueous humor.

Diabetes mellitus is a multiorgan systemic disease impacting numerous ocular structures that results in significant ocular morbidity and often results in more frequent corneal and glaucoma surgeries for affected individuals. We hypothesize that the systemic metabolic and proteomic derangement observed in the progression of diabetes influences the composition of the aqueous humor (AH), which ultimately impacts the anterior segment health of the eye. To identify changes associated with diabetes progression, we mapped the metabolite profile and proteome of AH samples from patients with varying severities of type II diabetes (T2DM).

Boston type 1 keratoprosthesis for primary congenital glaucoma.

Background/aims: To evaluate the Boston type 1 keratoprosthesis (KPro-1) in treatment of eyes with primary congenital glaucoma.

Methods: A retrospective review was performed of every eye with congenital glaucoma that was treated with a KPro-1 at a tertiary eye care centre between 1 January 2008 and 1 July 2014. The main outcome measures were visual outcome, prosthesis retention and postoperative complications.

Nerve injury and pain after operative repair of calcaneal fractures: a literature review.

Peripheral nerve injury is a common problem in foot and ankle surgery. We look at evidence of nerve injury as it relates to different operative approaches to the fractured calcaneus. The direct lateral, extended lateral, smile, sinus tarsi, and percutaneous approaches are discussed and the reported incidence of nerve injury in each is identified.

Vascular disruption of the talus: comparison of two approaches for triple arthrodesis.

Background: For triple arthrodesis, a single medial incision has been proposed to avoid lateral wound complications and has demonstrated satisfactory fusion rates. This study aimed to compare the disruption to the arterial supply of the talus between the single-medial-incision approach and the 2-incision approach.

Methods: The 2 approaches for triple arthrodesis were compared by analyzing the disruption of arterial vasculature in 14 cadaveric specimens in randomized fashion.