Publications by authors named "Jackson H Stocking"
Melanoma-derived brain metastases (MBM) represent an unmet clinical need because central nervous system progression is frequently an end stage of the disease. Immune checkpoint inhibitors (ICI) provide a clinical opportunity against MBM; however, the MBM tumor microenvironment (TME) has not been fully elucidated in the context of ICI. To dissect unique elements of the MBM TME and correlates of MBM response to ICI, we collected 32 fresh MBM and performed single-cell RNA sequencing of the MBM TME and T-cell receptor clonotyping on T cells from MBM and matched blood and extracranial lesions.
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- * We conducted two clinical trials to study the effectiveness of immune checkpoint inhibitors (ICI) in treating LMD and analyzed patient samples using advanced techniques like single-cell RNA sequencing.
- * Our research reveals important insights into the tumor environment in LMD and demonstrates the potential of using genomic profiling to enhance understanding and treatment strategies for this condition.
Article Synopsis
- Leptomeningeal disease (LMD) is a severe cancer complication often missed due to the low accuracy of current diagnostic methods like CSF cytology.
- This study aimed to evaluate if analyzing cell-free DNA (cfDNA) in CSF could provide a more reliable diagnosis for LMD compared to traditional cytologic methods.
- In a cohort of 30 patients, cfDNA analysis identified LMD correctly in 94% of follow-up samples, significantly outperforming cytologic analysis, indicating a potential improvement in diagnosing LMD.
Article Synopsis
- Most melanoma patients eventually stop responding to a type of treatment called immune checkpoint blockade (ICB), so researchers studied one patient’s tumor samples over 9 years.
- They found that different versions of the tumor were changing and adapting in unique ways, making it harder for the treatment to work.
- The study also showed that tumors could behave differently in various parts of the body, with some having more immune cells nearby than others, which can affect how well treatments work.