Publications by authors named "Jacklyn Levey"
Norrin (NDP) and WNT7A/B induce and maintain the blood-brain and blood-retina barrier (BBB, BRB) by stimulating the Frizzled4-LDL receptor related protein 5/6 (FZD4-LRP5/6) complex to induce beta-catenin-dependent signaling in endothelial cells (ECs). Recently developed agonists for the FZD4-LRP5 complex have therapeutic potential in retinal and neurological diseases. Here, we use the tetravalent antibody modality F4L5.
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- This research presents a method for effectively integrating reporter genes in zebrafish and mammalian cells using short DNA sequences for high precision.
- The approach utilizes a series of plasmids, known as pGTag, which incorporate CRISPR technology, allowing easy release of DNA sequences at targeted locations.
- Results showed high rates of successful gene targeting in zebrafish and efficient integration in human and pig cells, making the method practical and budget-friendly for various gene editing applications.