Publications by authors named "Jackie J D Han"
Calorie restriction (CR) has a positive impact on health and life span. Previous work, however, does not reveal the whole underlying mechanism of behavioral phenotypes under CR. We propose a new approach based on phase space reconstruction (PSR) to analyze the behavioral responses of mice to graded CR.
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- The study investigated the effects of calorie restriction (CR) on metabolic rates in mice, specifically focusing on how energy demands and basal metabolic rate (BMR) respond to varying levels of CR over three months.
- It was found that while there was a decline in unadjusted BMR with increased CR severity, the perceived metabolic suppression was likely due to inadequate predictive models rather than a true drop in metabolism.
- Ultimately, the research suggests that conclusions about metabolic changes from genetic and other interventions may actually stem from alterations in organ size and structure rather than at the cellular metabolism level.
Faced with reduced levels of food, animals must adjust to the consequences of the shortfall in energy. We explored how C57BL/6 mice withdrew energy from different body tissues during three months of food restriction at graded levels up to 40% (calorie restriction: CR). We compared this to the response to equivalent levels of protein restriction (PR) without a shortfall in calories.
View Article and Find Full Text PDFLimiting food intake attenuates many of the deleterious effects of aging, impacting upon healthspan and leading to an increased lifespan. Whether it is the overall restriction of calories (calorie restriction: CR) or the incidental reduction in macronutrients such as protein (protein restriction: PR) that mediate these effects is unclear. The impact of 3 month CR or PR, (10 to 40%), on C57BL/6 mice was compared to controls fed ad libitum.
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