Publications by authors named "Jackie Harney"
Introduction: The laboratory phenomenon of low dose hyper-radiosensitivity (LDHRS) describes excess cell kill at doses below 1 Gy relative to that predicted by the linear quadratic model. These data have stimulated the investigation of whether LDHRS can be exploited clinically.
Methods: Patients with metastatic tumor nodules to skin were recruited.
Background And Purpose: The laboratory phenomenon of low dose hyper-radiosensitivity (LDHRS) describes an excess of cell kill at doses below 1Gy relative to that predicted by the linear quadratic model. These data have stimulated clinical investigation into LDHRS in vivo.
Patients And Methods: Skin was used as a model of normal human tissue.
Purpose Of Review: This review examines the emerging role of agents that target tumour blood vessels in the treatment of glioma. It addresses the important issue of how these agents may best be combined with conventional radiation based therapies to optimize their effects, and reviews recent experimental and clinical data on which future treatment policies may be developed.
Recent Findings: Two main classes of agents can be used to influence tumour growth through their actions on the vasculature.