Publications by authors named "Jackie Chirinos"
J Clin Invest
October 2010
Article Synopsis
- TNFRSF25 (TNFR25) is a receptor found in CD4(+)FoxP3(+) Tregs, which have not been fully understood in terms of their function.
- Using a specific antibody (4C12), researchers found that activating TNFR25 led to a significant increase in Treg levels within just four days, making them 30%-35% of all CD4(+) T cells in the blood of mice.
- The expanded Tregs were highly effective in suppressing allergic lung inflammation in a mouse model for asthma, indicating TNFR25 plays a key role in Treg function and immune regulation.
