Publications by authors named "Jackelyn Meyer"
Article Synopsis
- The degradation of photoreceptor outer segments (POS) by retinal pigment epithelium (RPE) is crucial for vision, and issues with POS processing may lead to retinal diseases like Best disease (BD).
- Researchers used a human-induced pluripotent stem cell (hiPSC) model of BD and found altered protein degradation processes, characterized by increased protein oxidation and changes in protein secretion, linked to delayed POS digestion.
- Treatment with valproic acid (VPA) improved POS degradation, indicating a potential pharmacological target for addressing processing defects in BD and similar macular disorders.
Functional analysis of serially expanded human iPS cell-derived RPE cultures.
Invest Ophthalmol Vis Sci
October 2013
Purpose: To determine the effects of serial expansion on the cellular, molecular, and functional properties of human iPS cell (hiPSC)-derived RPE cultures.
Methods: Fibroblasts obtained from four individuals were reprogrammed into hiPSCs and differentiated to RPE cells using previously described methods. Patches of deeply pigmented hiPSC-RPE were dissected, dissociated, and grown in culture until they re-formed pigmented monolayers.