Application of a "staggered walk" algorithm for generating large-scale morphological neuronal networks.

Large-scale models of neuronal structures are needed to explore emergent properties of mammalian brains. Because these models have trillions of synapses, a major problem in their creation is synapse placement. Here we present a novel method for exploiting consistent fiber orientation in a neural tissue to perform a highly efficient modified plane-sweep algorithm, which identifies all regions of 3D overlaps between dendritic and axonal projection fields.