Publications by authors named "Jack Zhenhe Zhang"
Background: Necrotizing fasciitis (NF) is a rare but potentially life-threatening soft tissue infection. The objective of this study was to assess the association between timely surgery within 6 h and hospital mortality in patients with limb NF, and to describe the trends in patients with NF, time to surgery and standardized mortality ratio (SMR) over 11 years.
Methods: This was a multicenter, retrospective cohort study of all intensive care unit patients who had emergency surgery within 24 h of hospitalization for limb NF between April 1, 2008 and March 31, 2019 in Hong Kong.
Background: Sepsis surveillance using electronic health record (EHR)-based data may provide more accurate epidemiologic estimates than administrative data, but experience with this approach to estimate population-level sepsis burden is lacking.
Methods: This was a retrospective cohort study including all adults admitted to publicly-funded hospitals in Hong Kong between 2009-2018. Sepsis was defined as clinical evidence of presumed infection (clinical cultures and treatment with antibiotics) and concurrent acute organ dysfunction (≥2 point increase in baseline SOFA score).
Longitudinal studies on upper respiratory tract microbiome in coronavirus disease 2019 (COVID-19) without potential confounders such as antimicrobial therapy are limited. The objective of this study is to assess for longitudinal changes in the upper respiratory microbiome, its association with disease severity, and potential confounders in adult hospitalized patients with COVID-19. Serial nasopharyngeal and throat swabs (NPSTSs) were taken for 16S rRNA gene amplicon sequencing from adults hospitalized for COVID-19.
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- A study compared hospital outcomes between critically ill patients with COVID-19 and those with influenza A, focusing on mortality rates and risk factors.
- The research involved a retrospective analysis of adult patients in Hong Kong, matching 373 COVID-19 patients with 373 influenza A patients based on similar characteristics.
- Findings showed that COVID-19 patients had a significantly higher hospital mortality rate (17.5%) compared to influenza A patients (7.5%), with factors such as age and coinfections impacting these outcomes.
Article Synopsis
- - This study examined the outcomes of 940 critically ill patients with tuberculosis (TB) admitted to ICUs in Hong Kong over an 11-year period, finding high mortality rates of 24.7% in ICUs and 41.1% in hospitals, with a significant portion of ICU deaths occurring in patients who did not receive TB treatment.
- - Researchers used methods like generalized linear modeling and analyzed mortality trends, concluding that delays in TB treatment are linked to increased hospital mortality, and they noted that diagnostic methods like MTB PCR were underutilized.
- - The results suggest that despite TB being preventable and treatable, survival rates for ICU patients have not improved, emphasizing the need for quicker diagnoses and treatment to enhance patient
The effect of changes to cardiopulmonary resuscitation (CPR) procedures in response to Coronavirus disease 2019 (COVID-19) on in-hospital cardiac arrest (IHCA) management and outcomes are unreported. In this multicenter retrospective study, we showed that median time to arrival of resuscitation team has increased and proportion of patients receiving first-responder CPR has lowered during this pandemic. IHCA during the pandemic was independently associated with lower return of spontaneous circulation OR 0.
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