Publications by authors named "Jack Z Li"
Article Synopsis
- The study explored how the airway epithelium responds to SARS-CoV-2 and its variants, using airway organoids from 20 different subjects to better understand infection mechanisms.* -
- Tetraspanin-8 (TSPAN8) was identified as a key factor that enhances SARS-CoV-2 infection, working independently of the ACE2-Spike protein interaction.* -
- Although Delta and Omicron variants showed lower infection rates than the original virus, they still altered the epithelial response, indicating potential new targets for COVID-19 treatments with TSPAN8-blocking antibodies.*
Article Synopsis
- Surgery for early-stage lung cancer is the best cure option, but 30-50% of patients still experience recurrence after complete tumor removal.
- A study analyzed the genetic and immune profiles of recurrent lung tumors to better understand why this happens, revealing that recurrent tumors have more mutations and less immune activity compared to non-recurrent ones.
- Key findings suggest that recurrent tumors show signs of genomic instability and impaired immune responses, which may help them evade the immune system and lead to recurrence post-surgery.*
SARS coronavirus-2 (SARS-CoV-2) is causing a global pandemic with large variation in COVID-19 disease spectrum. SARS-CoV-2 infection requires host receptor ACE2 on lung epithelium, but epithelial underpinnings of variation are largely unknown. We capitalized on comprehensive organoid assays to report remarkable variation in SARS-CoV-2 infection rates of lung organoids from different subjects.
View Article and Find Full Text PDFMaternal focal atrial tachycardia during pregnancy: A systematic review.
J Cardiovasc Electrophysiol
November 2020
Introduction: The presentation and optimal management of maternal focal atrial tachycardia (AT) during pregnancy are unknown. The objective of this study is to conduct a comprehensive summary of the existing evidence.
Methods And Results: A systematic review of all reported cases of maternal focal AT during pregnancy was performed.
Article Synopsis
- The study investigates the timing of cardiac resynchronization therapy (CRT) in patients with new-onset left bundle branch block (LBBB) and idiopathic nonischemic cardiomyopathy (NICM).
- It compares clinical outcomes and heart function between patients who received CRT within 9 months of diagnosis versus those who waited longer.
- Results show that earlier CRT implantation (≤9 months) significantly improves heart function (LVEF) compared to later treatment, suggesting that prompt intervention could prevent further heart damage.
Acute aortic syndromes are among the most lethal of the cardiovascular diseases. Delays in recognition, diagnosis, and treatment are associated with increases in mortality. Signs and symptoms are sometimes subtle and atypical, and a high index of suspicion is useful to guide the diagnostic evaluation.
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