Publications by authors named "Jack Yongfeng Zhang"
Primatene MIST, an epinephrine metered-dose inhaler (MDI), has long been questioned by some medical professionals for asthma treatment despite having been approved by the Food and Drug Administration. One of the primary reasons for their concerns stemmed from potential cardiovascular complications following epinephrine administration. However, the majority of documented cardiovascular complications seemed to occur following the injection route of the epinephrine.
View Article and Find Full Text PDFRecently, the first generic glucagon for injection was approved for the treatment of severe hypoglycemia. Unlike its brand name recombinant glucagon, the generic glucagon is synthetic. Since glucagon has a high propensity to form aggregates in solution, it is essential to assess the aggregation profile of the synthetic glucagon compared to the recombinant glucagon.
View Article and Find Full Text PDFArticle Synopsis
- Glucagon, a hormone important for treating low blood sugar, is unstable in water and can change its structure into potentially harmful forms.
- The study focused on analyzing the secondary structure of glucagon using techniques like circular dichroism spectroscopy and 2D Nuclear Overhauser effect spectroscopy at both release and expiry.
- Results showed consistent structure components across both synthetic and recombinant glucagon, indicating no significant differences in their stability over time.
Article Synopsis
- - Glucagon for Injection is a hormone medication used for treating severe low blood sugar, and a generic version was recently approved by the FDA, though it is made differently from the brand-name version.
- - The brand-name glucagon is made using recombinant DNA, while the generic version uses peptide synthesis, potentially affecting impurities that could trigger immune responses.
- - A study used specific cell lines to test the immune response to both glucagon versions and found that the generic glucagon had negligible immunogenicity risks, similar to the brand-name product.