Publications by authors named "Jack Xu"

Background/objectives: Genicular artery embolization (GAE) has demonstrated potential as a treatment for knee osteoarthritis by targeting inflammation and pain, although current evidence remains limited. This study used imaging biomarkers to objectively assess synovitis and possible ischemic complications following GAE.

Methods: This was a prospective, single-center trial including participants with mild-to-moderate knee osteoarthritis.

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Article Synopsis
  • Right atrial thrombus is a rare but deadly condition, as seen in a 75-year-old man with underlying health issues who developed atrial flutter and had a thrombus found in his right atrial appendage during evaluation.
  • After the thrombus was confirmed through imaging, the patient was not a candidate for surgery and was prescribed apixaban while transitioning to hospice care.
  • This case underscores the lack of formal guidelines for treating right atrial thrombi, indicating a need for further research to establish management protocols and avoid complications.
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Background: Left atrial appendage occlusion (LAAO) is an alternative to anticoagulation for stroke prevention in select patients with atrial fibrillation (AF). In this study, we describe the case of a patient with delayed device-related thrombus (DRT) at 13 months post-LAAO in a setting of atrial stasis due to a worsening mitral bioprosthetic stenosis.

Case Summary: A 69-year-old woman with a history of rheumatic mitral stenosis and regurgitation post-bioprosthetic mitral valve replacement (6 years prior) and paroxysmal AF was referred for percutaneous LAAO due to recurrent severe gastrointestinal bleeding while on anticoagulation.

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A 76-year-old female with a complicated medical history presented for Watchman (Boston Scientific) placement 2 months after mitral valve transcatheter edge-to-edge repair (TEER). Preoperative workup before Watchman placement confirmed the presence of a thrombus in the left superior pulmonary vein. Post-procedure mitral valve TEER transesophageal echocardiogram showed no thrombus in the left atrium appendage or pulmonary veins.

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Infective endocarditis (IE) is a life-threatening cardiac infection usually associated with cardiac valves. Left atrial (LA) mural endocarditis is rarely seen and occurs in isolation or in conjunction with mitral valve endocarditis. We present a case of a 61-year-old male with no prior cardiac history who presented with melena and fevers.

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A 51-year-old male with a complicated medical history presented with shortness of breath. Preoperative workup confirmed the presence of a large atrial mass. However, delayed gadolinium enhancement CMR with long inversion time (TI 600) showed lack of enhancement, which was suggestive of a thrombus.

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Purpose: To evaluate the diagnostic capabilities of a supplementary color ramped iodine density map compared to virtual monoenergetic images (VMIs) at 74 keV in the diagnosis of acute bowel ischemia (ABI).

Methods: Data for this study were prospectively gathered and retrospectively evaluated. Patients referred to the Department of Diagnostic Radiology between October 2020 and August 2022 on the suspicion of ABI and underwent surgery < 12 h following fast kV-switching venous phase abdominal dual-energy CT (DECT) were consecutively included.

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The lower esophageal sphincter (LES) controls the passage into the stomach and prevents reflex of contents into the esophagus. Dysfunctions of this region typically involves impairment of muscular function, leading to diseases including gastro-esophageal reflux disease and achalasia. The main objective of this study was to develop a finite element model from a unique human LES dataset reconstructed from an ultra-mill imaging setup, and then to investigate the effect of anatomical characteristics on intraluminal pressures.

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Purpose: To compare noise, contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR) and image quality using deep-learning image reconstruction (DLIR) vs. adaptive statistical iterative reconstruction (ASIR-V) in 0.625 and 2.

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Constrictive pericarditis (CP) is a type of diastolic heart failure caused by an inelastic pericardium that impairs cardiac filling. Diagnosing CP can be challenging, and a variety of imaging techniques may be necessary. We present a unique case of severely calcified pericardium leading to CP.

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This case report describes a patient with bioprosthetic mitral valve dehiscence that resulted in severe paravalvular regurgitation and cardiogenic shock. Due to prohibitive surgical risk, valve-in-valve transcatheter mitral valve replacement was attempted but did not reduce the severity of the prosthetic paravalvular leak (PVL) severity. Subsequent percutaneous PVL closure with a ventricular septal defect occluder successfully reduced the PVL severity and led to significant clinical improvement.

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Article Synopsis
  • The gastro-esophageal junction (GEJ) is crucial for controlling food entry into the stomach and preventing acid reflux, with dysfunctions leading to symptoms like reflux and heartburn.
  • This study created a finite element model of the GEJ using human cadaver data from advanced imaging techniques, which was then compared to a previous model.
  • Results showed the new model was shorter and had lower pressure values, providing a foundation for further exploration of pressure dynamics during swallowing and the potential development of treatments.
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  • Incidental findings from abdominal CT scans are common and can lead to further tests that have both financial and health implications for patients.
  • This study compared dual-energy CT (DECT) and conventional contrast-enhanced CT in identifying and characterizing incidental mass lesions in the abdomen with 96 patients involved.
  • Results showed that DECT enhanced the detection of relevant lesions, indicating it may be a better option for immediate assessment than standard CT.
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Objectives: To evaluate a novel deep learning image reconstruction (DLIR) technique for dual-energy CT (DECT) derived virtual monoenergetic (VM) images compared to adaptive statistical iterative reconstruction (ASIR-V) in low kiloelectron volt (keV) images.

Methods: We analyzed 30 venous phase acute abdominal DECT (80/140 kVp) scans. Data were reconstructed to ASIR-V and DLIR-High at four different keV levels (40, 50, 74, and 100) with 1- and 3-mm slice thickness.

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The AngioVac transcatheter aspiration system (Angiodynamics) is used to percutaneously extract thrombi as well as vegetations typically growing from the right heart. We report a case of a failed mitral stented bioprosthesis due to a large vegetation that was treated successfully with AngioVac evacuation through a transseptal puncture followed by valve-in-valve intervention in the same setting.

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We assessed the correlation between liver fat percentage using dual-energy CT (DECT) and Hounsfield unit (HU) measurements in contrast and non-contrast CT. This study included 177 patients in two patient groups: Group A ( = 125) underwent whole body non-contrast DECT and group B ( = 52) had a multiphasic DECT including a conventional non-contrast CT. Three regions of interest were placed on each image series, one in the left liver lobe and two in the right to measure Hounsfield Units (HU) as well as liver fat percentage.

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Article Synopsis
  • * A meta-analysis of 10 studies with 1,462 patients found no increase in stroke or mortality risk associated with HALT, although it was linked to a higher post-TAVR aortic valve gradient.
  • * The study also hinted at trends showing a higher risk of HALT in men and a lower risk in patients with chronic kidney disease (CKD), but these findings weren't statistically significant, indicating a need for further research.
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Caseous calcification of mitral annulus is a rare variant of mitral annulus calcification that can mimic infective endocarditis, myocardial abscess, valve myxoma, or papillary fibroelastoma. On transthoracic echocardiography, the mass appears as a large, round echodense structure with a large calcification and central echolucency. We present a case of a 72-year-old female with a past medical history significant for diabetes mellitus, hypertension, and end-stage renal disease who was noted to have caseous calcification of the mitral annulus on transthoracic echocardiography, which was done as part of a preoperative kidney transplantation evaluation.

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A 63-year-old female with a history of hypertension presented with progressively worsening shortness of breath. She underwent a cardiac catheterization and was found to have prominent Thebesian veins as well as anomalous connections between the proximal right coronary artery and the right ventricle. Cardiac computed tomography was ordered for further evaluation and showed a coronary fistula to the right ventricular outflow tract confirming the diagnosis of a coronary-cameral fistula (CCF).

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Dual-energy CT (DECT) is an emerging imaging technique and has become increasingly available in Danish hospitals in recent years. DECT utilizes data acquired from high and low kV photons. This allows for the separation of materials based on their atomic buildup, which can be visualised and quantified during post-processing.

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Dual-energy computed tomography (DECT) can estimate tissue vascularity and perfusion via iodine quantification. The aim of this systematic review was to outline current and emerging clinical applications of iodine quantification within the gastrointestinal tract using DECT. The search was conducted with three databases: EMBASE, Pubmed and The Cochrane Library.

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Tetralogy of Fallot (ToF) is the most common cyanotic congenital heart disease, making up 10% of all congenital heart defects. Annual follow-up echocardiograms are recommended in patients with repaired ToF, but evidence-based guidelines do not exist. We hypothesized that most echocardiograms performed in asymptomatic patients with repaired ToF and no physical exam change do not result in an actionable change (AC) in management.

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Background: To describe an unusual presentation of acquired hypoventilation syndrome treated successfully with noninvasive positive pressure ventilation.

Case Presentation: We report a case report of a 48-year-old male who presented to the emergency room for recurrent syncope. He was found to have a ventricular colloid cyst causing uncal herniation.

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Article Synopsis
  • New onset post-operative atrial fibrillation (POAF) can occur after both cardiac and non-cardiac surgeries, but there's limited research on their long-term outcomes regarding AF recurrence and stroke incidence.
  • A study followed 112 patients with POAF, finding that those who had cardiac surgery exhibited a higher AF recurrence rate within 30 days post-discharge compared to those who had non-cardiac surgery, although long-term risks for strokes were similar.
  • The findings suggest that while there is a notable recurrence of AF in both groups, the risks for recurring AF and ischemic strokes are not significantly different, highlighting the need for ongoing monitoring of patients post-surgery.
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