Publications by authors named "Jack X Cimino"

Dopamine D receptor agonists improve spatial working memory, but their effects on temporal order memory, particularly prone to the effects of aging, have not been studied. Two D agonists, PF6256142 (PF) and 2-methyldihydrexidine (2MDHX), were examined for their effects in a rodent temporal order recognition task. Our results are consistent with the hypothesis that there is an age-related decline in rodent temporal order memory.

View Article and Find Full Text PDF

Rationale: Dopamine D receptor agonists have been shown to improve working memory, but often have a non-monotonic (inverted-U) dose-response curve. One hypothesis is that this may reflect dose-dependent differential engagement of D signaling pathways, a mechanism termed functional selectivity or signaling bias.

Objectives And Methods: To test this hypothesis, we compared two D ligands with different signaling biases in a rodent T-maze alternation task.

View Article and Find Full Text PDF