Publications by authors named "Jack Wolfsdorf"
Objective: To investigate clinical and demographic factors affecting the nature of end-of-life decisions and pediatric palliative care.
Design: Charts of 236 expired children were retrospectively reviewed for presence of endof- life care (EOLC) discussions and spiritual support, the nature of EOLC decisions, and the degree of opioid analgesics (OA) and sedatives (SDT) administration.
Results: Approximately 60% of patients had EOLC discussion, of whom 87.
Purpose: The criteria for starting extracorporeal membrane oxygenation (ECMO) therapy in term newborn patients with hypoxemic respiratory failure consist of an oxygenation index (OI) of 25 or higher and alveolar-arterial oxygen (Aao(2)) gradient of more than 600 at sea level. In such conditions, inhaled nitric oxide (iNO) may improve oxygenation and reduce the need for ECMO therapy. We studied early changes in OI and Aao(2) gradients in response to iNO treatment that may indicate a need to continue iNO treatment or the necessity to start an ECMO therapy.
View Article and Find Full Text PDFIntroduction: Clinical application of arteriovenous (AV) extracorporeal membrane oxygenation (ECMO) requires assessment of cardiovascular ability to respond adequately to the presence of an AV shunt in the face of acute lung injury (ALI). This ability may be age dependent and vary with the experimental model. We studied cardiovascular stability in a lamb model of severe ALI, comparing conventional mechanical ventilation (CMV) with AV-ECMO therapy.
View Article and Find Full Text PDFArticle Synopsis
- Phosphodiesterase inhibitors like aminophylline were tested for their ability to reduce inflammation and improve endothelial function during endotoxemia in a rat model.
- The study involved administering aminophylline and endotoxin to different groups of anesthetized rats while monitoring their gas exchange, blood pressure, and heart rate over 6 hours.
- While aminophylline did not prevent the adverse effects of endotoxemia during sepsis, it showed some improvement in acid-base balance in control rats, suggesting further research is needed to explore effective dosages.
Background: Splanchnic perfusion following hypovolemic shock is an important marker of adequate resuscitation. We tested whether the gap between esophageal partial carbon dioxide tension (PeCO2) and arterial partial carbon dioxide tension (PaCO2) is increased during graded hemorrhagic hypotension and reversed after blood reinfusion, using a fiberoptic carbon dioxide sensor.
Materials And Method: Ten Sprague-Dawley rats were anesthetized, tracheotomized, and cannulated in one femoral artery and vein.