Design and Synthesis of Imidazole and Triazole Pyrazoles as CYP121A1 Inhibitors.

The emergence of untreatable drug-resistant strains of is a major public health problem worldwide, and the identification of new efficient treatments is urgently needed. cytochrome P450 CYP121A1 is a promising drug target for the treatment of tuberculosis owing to its essential role in mycobacterial growth. Using a rational approach, which includes molecular modelling studies, three series of azole pyrazole derivatives were designed through two synthetic pathways.