Publications by authors named "Jack T Jagielski"
Article Synopsis
- - The study investigates isolated REM sleep behavior disorder (iRBD) and its links to neurodegenerative diseases, focusing on gender differences and younger adults, which are less explored compared to older males.
- - Researchers followed 372 participants (186 women and 186 men with iRBD), finding that women were diagnosed at a younger age than men and that over 12% converted to a neurodegenerative disorder within roughly 6 years.
- - Key findings indicate that older age at diagnosis is a significant factor for phenoconversion risk, with lower risk observed in those using antidepressants or having chronic pain, while higher risk was noted in individuals with vascular issues.
Study Objectives: Accurate diagnosis of isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is crucial due to its injury potential and neurological prognosis. We aimed to analyze visual and automated REM sleep without atonia (RSWA) diagnostic thresholds applicable in varying clinical presentations in a contemporary cohort of patients with iRBD using submentalis (SM) and individual bilateral flexor digitorum superficialis (FDS) and anterior tibialis electromyography limb recordings during polysomnography.
Methods: We analyzed RSWA in 20 patients with iRBD and 20 age-, REM-, apnea-hypopnea index-matched controls between 2017 and 2022 for phasic burst durations, density of phasic, tonic, and "any" muscle activity (number of 3-second mini-epochs containing phasic or tonic muscle activity divided by the total number of REM sleep 3-second mini-epochs), and automated Ferri REM atonia index (RAI).
Background: Isolated REM sleep behavior disorder (RBD) is a potentially injurious parasomnia lacking an established treatment. Ulotaront is a trace amine-associated receptor 1 (TAAR1) agonist with 5-HT receptor agonist activity that has demonstrated efficacy in patients with schizophrenia. In a single dose challenge study in humans, ulotaront 50 mg demonstrated significant REM suppressant effects.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to compare the apnea-hypopnea index (AHI) from a home sleep apnea test (PAT-HSAT) and an under-mattress device (WSA) over multiple nights in patients suspected of having obstructive sleep apnea (OSA).
- 35 out of 61 enrolled patients completed the study, with results showing that the WSA-AHI significantly differed from the PAT-AHI, both under different desaturation criteria.
- Although the WSA provides undisruptive AHI estimates, its accuracy compared to PAT-AHI varies, suggesting that further research is needed to refine its clinical application.
Background: Rapid eye movement (REM) sleep behavior disorder (RBD) occurs occasionally in essential tremor (ET), but polysomnographic REM sleep without atonia (RSWA) analyses have been sparse.
Objective: To characterize the amount and distribution of polysomnographic RSWA, the electrophysiologic substrate of RBD, in patients with Parkinson's disease (PD) and ET.
Methods: We analyzed quantitative RSWA in 73 patients: PD (23), ET (23), and age-sex-matched controls (27).