Publications by authors named "Jack T Adams"
J Exp Clin Cancer Res
January 2024
Article Synopsis
- Targeted therapies, such as small molecule inhibitors for aberrant kinase signaling and chromatin regulators, show promise in treating high-grade gliomas (HGG), but typically result in only temporary responses.
- Recent research highlights the collaboration between epigenetic regulators and kinase signaling networks, which contributes to the aggressive nature of the gliomas and their resistance to treatment.
- This review focuses on five key chromatin regulators with potential for pharmacological targeting, emphasizing that combining the inhibition of these regulators with kinase signaling could enhance treatment effectiveness in HGG, improving patient outcomes.
