The ovaries of transgender men indicate effects of high dose testosterone on the primordial and early growing follicle pool.

Androgens are essential in normal ovarian function and follicle health but hyperandrogenism, as seen in polycystic ovary syndrome, is associated with disordered follicle development. There are few data on the effect of long-term exposure to high levels of testosterone as found in transgender men receiving gender-affirming endocrine therapy. In this study, we investigate the effect of testosterone on the development, morphological health and DNA damage and repair capacity of human ovarian follicles in vivo and their survival in vitro.

Climate change and coastal resiliency of Suva, Fiji: a holistic approach for measuring climate risk using the climate and ocean risk vulnerability index (CORVI).

Unlabelled: Coastal cities are under severe threat from the impacts of climate change, such as sea-level rise, extreme weather events, coastal inundation, and ecosystem degradation. It is well known that the ocean, and in particular coastal environments, have been changing at an unprecedented rate, which poses increasing risks to people in small island developing states, such as Fiji. The Greater Suva Urban Area, the capital and largest metropolitan area of Fiji, is expected to be largely impacted by climate-related risks to its socio-economic, cultural, and political positions.

Gabapentin for the Management of Chronic Pelvic Pain in Women (GaPP1): A Pilot Randomised Controlled Trial.

Chronic pelvic pain (CPP) affects 2.1-24% of women. Frequently, no underlying pathology is identified, and the pain is difficult to manage.

Massive spontaneous hemothorax during the immediate postpartum period.

Nontraumatic hemothorax is a rare cause of postpartum respiratory distress. We present a case of massive spontaneous hemothorax, which presented during the immediate postpartum period and was initially treated as pulmonary embolism. Further investigation revealed a tiny lung nodule: although pulmonary arteriovenous malformation was considered, the imaging appearances tended to counter this interpretation.

Female sterilisation: a cohort controlled comparative study of ESSURE versus laparoscopic sterilisation.

Objective: To compare patient satisfaction, discomfort, procedure time, success rate and adverse events of hysteroscopic (ESSURE, Conceptus Inc, San Carlos, USA) versus laparoscopic sterilisation.

Design: Cohort controlled comparative study.

Setting: The day surgery and outpatient unit of three large UK hospitals.

A randomised controlled trial of microwave endometrial ablation without endometrial preparation in the outpatient setting: patient acceptability, treatment outcome and costs.

Objective: To compare outpatient microwave endometrial ablation (MEA) in the postmenstrual phase to standard MEA treatment after drug preparation in a day case theatre environment.

Design: A randomised controlled trial.

Setting: A large United Kingdom teaching hospital.

Microwave endometrial ablation vs. rollerball electroablation for menorrhagia: a multicenter randomized trial.

Study Objective: To compare the effectiveness, safety, and acceptability of microwave endometrial ablation (MEA) with those of rollerball electroablation (REA) for the treatment of menorrhagia.

Design: Randomized clinical trial (Canadian Task Force classification I).

Setting: Eight academic medical centers and private medical practices.