XDoppler: Cross-Correlation of Orthogonal Apertures for 3D Blood Flow Imaging.

Row column addressing (RCA) transducers have the potential to provide volumetric imaging at ultrafast frame rate using a low channel count over a large field of view. In previous works we have shown that vascular imaging of large arteries as well as functional neuroimaging of the rat brain were feasible using RCA orthogonal plane wave imaging (OPW), but these applications required to transmit many plane waves, significantly reducing the frame rate. In this study, we introduce XDoppler imaging, a novel method to increase the performances of RCA flow imaging by taking advantage of the blood spatial decorrelation statistics combined with the limited spatial overlap of the point spread functions (PSF) of the two orthogonal apertures of the RCA transducer.

4D Functional Imaging of the Rat Brain Using a Large Aperture Row-Column Array.

Functional ultrasound imaging (fUS) recently emerged as a promising neuroimaging modality to image and monitor brain activity based on cerebral blood volume response (CBV) and neurovascular coupling. fUS offers very good spatial and temporal resolutions compared to fMRI gold standard as well as simplicity and portability. It was recently extended to 4D fUS imaging in preclinical settings although this approach remains limited and complex.