Publications by authors named "Jack Janetzki"
Background: Fluoroquinolones (FQs) are commonly used to treat urinary tract infections (UTIs), but some studies have suggested they may increase the risk of aortic aneurysm or dissection (AA/AD). However, no large-scale international study has thoroughly assessed this risk.
Methods: A retrospective cohort study was conducted using a large, distributed network analysis across 14 databases from 5 countries (United States, South Korea, Japan, Taiwan, and Australia).
Utilisation Trends of Lisdexamfetamine: Insights From Recent Medicine Shortages in Australia.
Pharmacoepidemiol Drug Saf
February 2025
Purpose: Investigate the impact of recent notified medicine shortages on dispensing patterns of 30, 40, 50, and 60 mg strengths of lisdexamfetamine for treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Australia.
Methods: Pharmaceutical Benefits Scheme (PBS) aggregate dispensing data for 2022-2024 were analysed. Monthly dispensings and Defined Daily Doses (DDDs) for lisdexamfetamine were calculated overall and by product strength.
Premature mortality in people living with a severe mental illness (SMI) is often attributed to multiple factors including the use of medicines such as antipsychotics. Second-generation antipsychotics (SGAs) are known to cause metabolic syndrome which can increase the risk of cardiovascular disease. Practice guidelines have recommended regular physical health monitoring, particularly of metabolic parameters, however, metabolic monitoring for people living with SMI using antipsychotics remains suboptimal.
View Article and Find Full Text PDFInnovations in pharmacovigilance studies of medicines in older people.
Br J Clin Pharmacol
January 2025
Article Synopsis
- Pharmacovigilance is the science focused on detecting and preventing adverse effects related to medicines and vaccines, as defined by the WHO.
- It's especially crucial for older adults, who are often left out of clinical trials, because they frequently take multiple medications and have various health conditions.
- The review discusses new methods in pharmacovigilance that use digital health technologies and real-world data to better identify and assess medication-related risks for older populations.
To investigate the perception of community pharmacists on the down-scheduling of 5-HT3 antagonists to pharmacist-only-medicine for treatment of acute nausea and/or vomiting in Australia. A nationwide anonymous survey targeting Australian community pharmacists was conducted from April to May 2023. Responses were collected and analysed quantitively or qualitatively, where appropriate.
View Article and Find Full Text PDFIntroduction: This feasibility study aims to develop and test a new model of practice in Australia using digital technologies to enable pharmacists to monitor early signs and symptoms of medicine-induced harms in residential aged care.
Methods And Analysis: Thirty residents will be recruited from an aged care facility in South Australia. The study will be conducted in two phases.
Article Synopsis
- A study investigated the effects of 40 potential medicines as inhibitors of glutathione peroxidase 1 (GPx1) on the development and progression of chronic obstructive pulmonary disease (COPD) using data from Australia's Pharmaceutical Benefits Scheme from 2013 to 2019.
- Findings showed that 21 out of the 40 index medicines were linked to adverse drug event (ADE) signals indicating the risk of developing or worsening COPD, including atenolol and naproxen.
- The study concluded that while signals were identified for several GPx1 inhibitors, more extensive research is needed to validate these findings.
Article Synopsis
- - Chronic Obstructive Pulmonary Disease (COPD) involves declining lung function and increased oxidative stress due to reduced antioxidant enzyme activity, specifically Glutathione Peroxidase 1.
- - A study examined how certain drugs might inhibit Glutathione Peroxidase 1, using computer modeling to predict drug interactions and searching a database for related adverse events.
- - Results revealed that some common medications, like acetylsalicylic acid and atenolol, may inhibit this enzyme and are linked to adverse effects in COPD, highlighting the need for ongoing drug safety evaluations.
Objectives: During the COVID-19 pandemic, Australian community pharmacists delivered a wide range of professional services, including COVID-19 vaccinations. The aim of this study was to understand the reasons for and attitudes of consumers receiving COVID-19 vaccinations from community pharmacists.
Methods: A nationwide anonymous online survey recruited consumers above the age of 18 years who had received their COVID-19 vaccinations at community pharmacies between September 2021 and April 2022.
What Is Known And Objective: Proton pump inhibitors (PPIs), used to treat and prevent gastro-oesophageal conditions, are well-tolerated but have been associated with risk including pneumonia. The extent to which initiation of PPIs can contribute to other respiratory conditions such as chronic obstructive pulmonary disease (COPD) is largely unknown.
Methods: A sequence symmetry analysis (SSA) approach was applied to the Australian Department of Human Services, Pharmaceutical Benefits Scheme 10% extract.