Publications by Jack J Mesojedec

Publications by authors named "Jack J Mesojedec"

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Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS.

Michael E Bekier Emile Pinarbasi Jack J Mesojedec Layla Ghaffari Martina de Majo

bioRxiv

January 2025

Cytoplasmic TDP43 mislocalization and aggregation are pathological hallmarks of amyotrophic lateral sclerosis (ALS). However, the initial cellular insults that lead to TDP43 mislocalization remain unclear. In this study, we demonstrate that Nemo-like kinase (NLK)-a proline-directed serine/threonine kinase-promotes the mislocalization of TDP43 and other RNA-binding proteins by disrupting nuclear import.

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