Publications by authors named "Jack Huang"

Chondroid syringomas are rare adnexal neoplasms composed of epithelial and mesenchymal components, posing diagnostic challenges due to their diverse histological features. We report an atypical presentation of an apocrine mixed tumor in a 51-year-old female patient who presented with a 0.7 cm firm, flesh-colored nodule on the right lateral cutaneous lip.

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Editors' selections from the current scientific literature.

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Objectives: To assess hotspot micro-vessel flow velocity waveforms in human papillomavirus (HPV) cervical infections using transvaginal power Doppler ultrasound (TV-PDU) and explore associations with high-grade squamous intraepithelial lesions (HSIL, cervical intraepithelial neoplasia [CIN] II and III).

Methods: In all, 62 patients with confirmed HPV-HSIL (14 CIN II, 48 CIN III) and 65 age- and parity-matched women with neither HPV infection nor CIN were compared. Seven parameters by TV-PDU were used to assess vascular classification and micro-vessel flow velocity, including vascular grading (class I, II, III), lowest pulsatility index (PI), resistance index (RI), peak systolic velocity (PS), end-diastolic velocity (ED), time average maximum velocity (TAMV), and the vascular index (VI = PS/ED).

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A FMCW LiDAR system of both the distributed feedback laser and external cavity laser is established in baseband beat notes, rather than up-conversion to an intermediate frequency to exclude flicker noise. Meanwhile, utilizing fast-scanning MEMS mirrors, high-quality real-time (1 fps) 4-D images of the slow-moving object (10 mm/s) can be directly constructed at the baseband with a central frequency as low as 100 kHz and a small Doppler shift. The proposed LiDAR architecture based on such a low-frequency baseband significantly improves the optical power budget on the transmitter side and eliminates the costly high-speed sampling circuits on the receiver side.

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Article Synopsis
  • Male infertility is largely caused by declining semen quality, prompting innovations in sperm sorting technologies to improve assisted reproductive methods.
  • The TRMC (thermotaxis and rheotaxis microfluidic) device sorts sperm efficiently in just 15 minutes by mimicking natural processes, significantly increasing the percentage of viable sperm with improved motility and DNA integrity.
  • Results show a surge in progressive sperm from 3.90% to 96.11%, a 69% boost in motility, and a 90% improvement in DNA integrity, making the TRMC device a promising tool for in vitro fertilization and other fertility treatments.
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Purpose: The purposes of this study were to determine whether biomechanical properties of mature oocytes could predict usable blastocyst formation better than morphological information or maternal factors, and to demonstrate the safety of the aspiration measurement procedure used to determine the biomechanical properties of oocytes.

Methods: A prospective split cohort study was conducted with patients from two IVF clinics who underwent in vitro fertilization. Each patient's oocytes were randomly divided into a measurement group and a control group.

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Article Synopsis
  • - The study aimed to establish reference values for fetal aortic blood flow during the first trimester using high-definition flow imaging (HDFI) and explored the relationship between aortic blood flow and fetal measurements such as nuchal thickness, crown-rump length, and heartbeat.
  • - An analysis of 262 fetuses was conducted from December 2022 to December 2023, measuring various aortic blood flow parameters via 2D power Doppler ultrasound, including peak systolic velocity and indices related to blood flow resistance and pulsatility.
  • - Key findings showed a positive correlation between gestational age and several aortic blood flow metrics, while some, like the aortic isthmic systolic index, decreased with age
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Despite serum progesterone being a widely accepted method for luteal phase support during embryo transfer cycles, debates persist regarding the optimal strategy for guiding clinical decisions on progesterone dosages to maximize reproductive outcomes. This retrospective study explored the utility of microRNA (miRNA) biomarkers in guiding personalized progesterone dosage adjustments for frozen embryo transfer (FET) cycles in 22 in vitro fertilization (IVF) patients undergoing hormone replacement therapy. Utilizing MIRA, an miRNA-based endometrial receptivity test, we analyzed patients' miRNA expression profiles before and after progesterone dosage adjustments to determine suitable dosages and assess endometrial status.

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Article Synopsis
  • Advances in IVF have not completely resolved embryo implantation failures, with one key issue being the "displaced window of implantation" (WOI), where the timing of embryo transfer does not sync with the uterine environment.
  • The study aims to create a miRNA-based classifier to pinpoint the optimal timing for embryo transfer by analyzing miRNA expression profiles from 200 IVF patients.
  • The developed classifier showed high accuracy (93.9% in the training set and 88.5% in the testing set) in identifying the correct WOI, indicating its potential to improve IVF outcomes.
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Article Synopsis
  • * Recent research highlights that cell-free miRNAs from blood samples can be a non-invasive way to analyze endometrial receptivity, potentially replacing traditional methods.
  • * In this study, 111 blood samples were examined using advanced sequencing, achieving a high accuracy of 95.9% in predicting endometrial receptivity status, with significant differences in miRNA expression noted between various receptivity stages.
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The enhancement in responsivity of photodiodes (PDs) or avalanche photodiodes (APDs) with the traditional flip-chip bonding package usually comes at the expense of degradation in the optical-to-electrical (O-E) bandwidth due to the increase of parasitic capacitance. In this work, we demonstrate backside-illuminated InAlAs based APDs with novel flip-chip bonding packaging designed to relax this fundamental trade-off. The inductance induced peak in the measured O-E frequency response of these well-designed and well-packaged APDs, which can be observed around its 3-dB bandwidth (∼30 GHz), effectively widens the bandwidth and becomes more pronounced when the active diameter of the APD is aggressively downscaled to as small as 3 µm.

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We have conducted cervical imaging of uterine and micro-vessel flow velocity waveforms in acute pelvic inflammatory disease (PID) by transvaginal power Doppler ultrasound (TVPDU) in order to explore the associations of sonographic parameters with simple and complex cervicitis. Thirty-eight patients with acute PID (26 with acute simple cervicitis and 12 with complex cervicitis) were enrolled for an assessment of vascular grading of cervix and micro-vessel flow velocity using TVPDU before treatment. Seven parameters, including vascular grading (VG), lowest pulsatility index (PI), resistance index (RI), peak systolic velocity (PS), end diastolic velocity (ED), time average maximum velocity (TAMV), and vascular index (VI = PS/ED), were measured and recorded.

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Article Synopsis
  • - The study focuses on the importance of building organizational capacity in hospitals engaged in payment models like bundled payments and accountable care organizations, specifically highlighting co-participant hospitals that have experience with both models.
  • - A national survey of 424 American Hospital Association member hospitals was conducted, revealing that both co-participant and bundled payment hospitals have strong capabilities in performance feedback and using health IT for risk assessment, with a notable 38% response rate.
  • - While care management capacities were similar across both groups, bundled payment hospitals demonstrated better utilization of postacute care providers, suggesting that hospitals with experience in multiple payment models might adopt different strategies compared to those with experience in just one model.
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We demonstrate a top-illuminated high-speed uni-traveling carrier photodiode (UTC-PD) with a novel design in the p-type absorber, which can effectively shorten the photon absorption depth at telecommunication wavelengths (1.31~1.55 μm) and further enhance the bandwidth-efficiency product of UTC-PD.

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Objective: To assess the impact of a campus community health worker program (HealthPALs) on student influenza vaccination.

Participants: Undergraduate students at a northeastern US university (enrollment 6650), influenza seasons 2011-2012 through 2015-2016.

Methods: Study design: Difference-in-differences analysis of student vaccination at campus dormitory influenza clinics during intervention vs.

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While financial incentives to providers or patients are increasingly common as a quality improvement strategy, their impact on patient subgroups and health care disparities is unclear. To examine these patterns, we analyzed data from a randomized clinical trial of financial incentives to lower low-density lipoprotein (LDL) cholesterol levels in patients at risk for cardiovascular disease. Patients with higher baseline LDL experienced greater cholesterol reductions in the shared incentive arm (0.

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Introduction: Maintaining the standard two-handed chest compression is difficult in high-speed ambulances in rural areas.

Methods: A retrospective, video-based, observational study was conducted from June to September 2013 in Nantou, a rural county of central Taiwan, to evaluate the chest compression fraction in an ambulance carriage during the travel from the scene to the hospital. The chest compression fraction was calculated as the chest compression time period divided by the ambulance travelling time period; the one-handed and two-handed chest compression fractions were also calculated.

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Assisted reproductive technologies (ART) encompass fertility treatments, which involve manipulations of both oocyte and sperm in vitro. This chapter provides a brief overview of ART, including indications for treatment, ovarian reserve testing, selection of controlled ovarian hyperstimulation (COH) protocols, laboratory techniques of ART including in vitro fertilization (IVF), and intracytoplasmic sperm injection (ICSI), embryo transfer techniques, and luteal phase support. This chapter also discusses potential complications of ART, namely ovarian hyperstimulation syndrome (OHSS) and multiple gestations, and the perinatal outcomes of ART.

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The efficacy of assisted reproductive technologies has improved significantly over the past decades. The main indications for in vitro fertilisation include tubal obstruction, severe male-factor infertility, severe endometriosis, ovulatory dysfunction, diminished ovarian reserve, and infertility of unexplained cause. In vitro fertilisation has also become an effective treatment option for couples wishing to undergo pre-implantation genetic diagnosis or screening, and for those wishing to cryopreserve their oocytes or embryos for preservation of fertility.

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The hydroxypyrroloindolenine (Hpi) motif forms the fundamental core of the pentacyclic natural product, brevianamide E, the concise stereoselective synthesis of which, via oxidative cyclization, is described.

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