Publications by authors named "Jack C F Liao"
Article Synopsis
- Researchers used plasmid DNA vaccines targeting specific cancer markers (melanosomal differentiation antigens) to stimulate immune responses against melanoma in mice, leading to the exploration of this approach in dogs.
- In a Phase I clinical trial, nine dogs with advanced melanoma received a human tyrosinase DNA vaccine, showing safety and a longer survival compared to historical controls.
- Three dogs developed antibodies specific to tyrosinase, indicating the vaccine's potential to overcome the dog's immune tolerance to its own proteins, which may correlate with their improved tumor control and survival rates.
The cyclin-dependent kinases (CDKs) that drive the eukaryotic cell cycle must be phosphorylated within the activation segment (T-loop) by a CDK-activating kinase (CAK) to achieve full activity. Although a requirement for CDK-activating phosphorylation is conserved throughout eukaryotic evolution, CAK itself has diverged between metazoans and budding yeast, and fission yeast has two CAKs, raising the possibility that additional mammalian enzymes remain to be identified. We report here the characterization of PNQALRE (also known as CCRK or p42), a member of the mammalian CDK family most similar to the cell-cycle effectors Cdk1 and Cdk2 and to the CAK, Cdk7.
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