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Publications by authors named "Jack Broitman"

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Effects of radiation type and delivery mode on a radioresistant eukaryote Cryptococcus neoformans.
Igor Shuryak Ruth A Bryan Jack Broitman Stephen A Marino Alfred Morgenstern

Nucl Med Biol

June 2015

Introduction: Most research on radioresistant fungi, particularly on human pathogens such as Cryptococcus neoformans, involves sparsely-ionizing radiation. Consequently, fungal responses to densely-ionizing radiation, which can be harnessed to treat life-threatening fungal infections, remain incompletely understood.

Methods: We addressed this issue by quantifying and comparing the effects of densely-ionizing α-particles (delivered either by external beam or by (213)Bi-labeled monoclonal antibodies), and sparsely-ionizing (137)Cs γ-rays, on Cryptococcus neoformans.

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Synopsis of recent research by authors named "Jack Broitman"

  • - Jack Broitman's research primarily focuses on understanding the responses of the radioresistant eukaryote Cryptococcus neoformans to different types of radiation, paving the way for better treatment strategies for fungal infections.
  • - In his 2015 study published in "Nucl Med Biol," Broitman compares the effects of densely-ionizing α-particles and sparsely-ionizing γ-rays on this pathogenic fungus, highlighting the gaps in recent understandings of how these organisms react to various radiation types.
  • - The findings suggest that densely-ionizing radiation, particularly when delivered through targeted methods such as monoclonal antibodies, could potentially enhance treatment efficacy for fungal infections that are resilient to conventional therapies.

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