The assessment of infarct size in postmyocardial infarction patients undergoing thallium-201 tomographic imaging is improved using attenuation correction.

Purpose: Attenuation correction (ATC) has been shown to improve the accuracy of thallium-201 single photon emission computed tomography (SPECT) for the detection and evaluation of patients with coronary artery disease. The purpose of this study was to evaluate the value of ATC for the assessment of infarct size in patients after myocardial infarction (MI).

Materials And Methods: Tl-201 SPECT with ATC was performed on 39 patients with 49 previous MIs.

Noninvasive detection of collateral flow to the infarct-related coronary artery in patients after myocardial infarction by Tl-201 tomographic imaging.

Background: The determination of viability and perfusion within the infarct zone in post-myocardial infarction patients has both therapeutic and prognostic significance. Reversibility of thallium 201 uptake within the territory of the infarct-related coronary artery (IRA) as shown by single photon emission computed tomography (SPECT) is associated with a jeopardized but viable myocardium. We aimed to test the hypothesis that for post-myocardial infarction patients undergoing Tl-201 stress-redistribution SPECT, a scintigraphic pattern of distal reversibility without proximal reversibility within a defect corresponding to the IRA territory is a marker of collateral flow to the occluded culprit artery.

Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution.

Background: Systemic delivery of bone marrow-derived mesenchymal stem cells (BM-MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat model after myocardial infarction (MI).

Methods And Results: BM-MSCs were obtained from rat bone marrow, expanded in vitro to a purity of >50%, and labeled with 99mTc exametazime, fluorescent dye, LacZ marker gene, or bromodeoxyuridine.