Antidepressants in Surface Waters: Fluoxetine Influences Mosquitofish Anxiety-Related Behavior at Environmentally Relevant Levels.

Pharmaceutical contamination is an increasing problem globally. In this regard, the selective serotonin reuptake inhibitors (SSRIs)-a group of antidepressants-are particularly concerning. By disrupting the serotonergic system, SSRIs have the potential to affect ecologically important behaviors in exposed wildlife.

The pharmaceutical pollutant fluoxetine alters reproductive behaviour in a fish independent of predation risk.

Pharmaceutical pollutants constitute a major threat to wildlife because of their capacity to induce biological effects at low doses. One such pollutant is the antidepressant fluoxetine, which has been detected in surface waters globally at levels that recent studies suggest can alter physiology and behaviour in aquatic organisms. However, wildlife exposed to pharmaceutical contaminants are typically confronted with multiple stressors simultaneously, including predation risk, which is a particularly important natural stressor that can have direct (e.