Publications by authors named "Jack A Banagis"
Article Synopsis
- Isocitrate dehydrogenase (IDH)-mutant tumors rely heavily on NAD+ for survival, and the study explores how activating sirtuin (SIRT) enzymes, which consume NAD+, can affect these tumors.
- The research tested different methods of SIRT activation in IDH-mutant tumor lines, including gene editing and small molecules, revealing that activating Sirt1 significantly depletes NAD+ and enhances tumor cell death when combined with NAMPT inhibition.
- The results suggest that Sirt1 activation can specifically target IDH-mutant tumors using well-tolerated drugs (SIRT-activating compounds), potentially offering a less toxic treatment alternative compared to traditional chemotherapy.
