Publications by authors named "Jacinthe Gagnon"
Ribonuclease 6 (RNase 6) is one of eight catalytically active human pancreatic-type RNases that belong to a superfamily of rapidly evolving enzymes. Like some of its human homologues, RNase 6 exhibits host defense properties such as antiviral and antibacterial activities. Recently solved crystal structures of this enzyme in its nucleotide-free form show the conservation of the prototypical kidney-shaped fold preserved among vertebrate RNases, in addition to revealing the presence of a unique secondary active site.
View Article and Find Full Text PDFThe Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), a polycationic, amphiphilic and helical neuropeptide, is well known for its neuroprotective actions and cell penetrating properties. In the present study, we evaluated the potent antibacterial property of PACAP38 and related analogs against various bacterial strains. Interestingly, PACAP38 and related analogs can inhibit the growth of various bacteria including Escherichia coli (JM109), Bacillus subtilis (PY79), and the pathogenic Burkholderia cenocepacia (J2315).
View Article and Find Full Text PDFBiomaterial-related infections remain a significant challenge in medicine. Antimicrobial materials on the basis of Ag nanoparticles represent a promising solution for this issue. Therefore several Ag-containing nanocontainers and nanorattles have been synthesized and characterized that exhibit remarkable control over the release of Ag+ as antimicrobial active species.
View Article and Find Full Text PDFBoth enantiomers of trans-cyclohexane-1,2-diammonium sulfate and trans-1,2-diphenylethylenediammonium sulfate were used as "tailor-made" additives to direct the mirror-symmetry breaking in the attrition-enhanced deracemization (i.e. Viedma ripening) of conglomerate crystals of ethylenediammonium sulfate (EDS).
View Article and Find Full Text PDFArticle Synopsis
- This study focuses on improving the understanding and characterization of nanometer-thick organic monolayers used in various fields like biosensing and nanomedicine.
- DART-HRMS, a high-resolution mass spectrometry technique, was employed to analyze different types of monolayers on various substrates, revealing that substrate choice is crucial mainly for gold while showcasing how different chemical groups behave during analysis.
- The findings highlight DART-HRMS as a valuable tool for quickly and effectively studying the structure of organic monolayers, enabling better applications in smart materials and related technologies.
Complete asymmetric amplification of ethylenediammonium sulfate was achieved under continuous dissolution/crystallization conditions using an abrasion/grinding method.
View Article and Find Full Text PDFBackground: Although endoscopic sinus surgery has been widely used for the treatment of chronic rhinosinusitis, some patients fail to derive clinical benefit from this procedure. We evaluated the efficacy of a treatment regimen consisting of selective irrigation of diseased sinus mucosa with topical antibiotics and steroids in conjunction with oral antibiotics and steroids.
Methods: Twenty patients suffering from chronic rhinosinusitis and resistant to medical treatment (mean duration 3.