Publications by authors named "Jacinda Tran"
Background: Pre-exposure prophylaxis (PrEP) is key to ending the US HIV epidemic, but uptake remains low. Federal legislation permitting community pharmacists to initiate PrEP nationwide could expand access to PrEP services.
Objectives: This study aimed to evaluate census tract-level geospatial access to PrEP facilities and community pharmacies across the US and characterize geographic areas and populations where community pharmacies could help bridge the gap in care.
Article Synopsis
- Evidence comparing the effectiveness and safety of various ulcerative colitis therapies (UPA, VEDO, UST, TOFA) is limited, prompting a study using data from phase 3 trials.
- Three indirect comparisons were made focusing on UPA versus VEDO, UST, and TOFA, evaluating efficacy and safety outcomes after induction and maintenance phases.
- Results showed that UPA 15 mg and 30 mg had higher clinical response rates compared to the other treatments, with no significant safety concerns between UPA and the comparators.
Introduction: Women living with human immunodeficiency virus (WLHIV) face elevated risks of human papillomavirus (HPV) acquisition and cervical cancer (CC). Coverage of CC screening and treatment remains low in low-and-middle-income settings, reflecting resource challenges and loss to follow-up with current strategies. We estimated the health and economic impact of alternative scalable CC screening strategies in KwaZulu-Natal, South Africa, a region with high burden of CC and HIV.
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- In 2020, many people in Kenya with HIV weren't taking their medication regularly, which can help control the virus.
- Experts believe a new type of HIV treatment called long-acting antiretroviral therapy (LA-ART) could help more people stick to their treatment.
- The interviews showed that most experts liked the idea of injections and special pills that work longer to reduce the hassle of taking medicine every day, but some had worries about how these would be given and if they could affect things like having kids.
Background: This post hoc analysis of a large, phase 3 program evaluated the effects of upadacitinib on fatigue, bowel urgency, and abdominal pain in patients with moderately to severely active ulcerative colitis.
Methods: Induction data were pooled from 2 identical studies, the U-ACHIEVE induction and U-ACCOMPLISH studies. Patients in these studies received upadacitinib 45 mg once daily or placebo as induction treatment.
Background: We evaluated the health-related quality of life (HRQoL) benefits of upadacitinib (UPA) induction and maintenance treatment in a phase 3 study of patients with ulcerative colitis (UC) across a broad range of patient-centered outcomes.
Methods: Patients received UPA 45 mg once daily or placebo as induction treatment for 8 weeks. Patients who achieved clinical response were rerandomized to receive once daily UPA 15 mg, 30 mg, or placebo as maintenance treatment for 52 weeks.
Introduction: Our objective was to evaluate physicians' perspectives on the clinical utility of pharmacogenetic (PGx) testing in kidney, liver, heart, and lung transplantation (KLHL-Tx).
Methods: A 36-question web-based survey was developed and administered to medical and surgical directors of US KLHL-Tx centers.
Results: There were 82 respondents (10% response rate).
To assess stakeholder perspectives regarding the clinical utility of pharmacogenomic (PGx) testing following kidney, liver, and heart transplantation. We conducted individual semi-structured interviews and focus groups with kidney, liver, and heart transplantation patients and providers. We analyzed the qualitative data to identify salient themes.
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- Various genetic techniques help trace cell lineage during tissue development, with some focusing on spatial/temporal aspects and others linking gene expression to lineage.
- The G-TRACE system allows for quick visualization of GAL4 expression patterns, enabling genome-wide expression-based lineage studies conducted by UCLA students and high school scholars.
- Findings revealed new expression-based lineage patterns and were compiled into the G-TRACE Expression Database (GED), contributing to better student learning outcomes and retention in STEM fields.