Publications by authors named "Jacie Law"
Article Synopsis
- The study aimed to explore how the timing of immunotherapy affects survival rates in patients with resectable lung cancer by conducting a systematic review and meta-analysis of randomized controlled trials.
- A total of 865 studies were screened, resulting in 4425 participants being analyzed; the findings indicated that timing (neoadjuvant, peri-operative, or post-operative) influences survival, with the neoadjuvant group showing the most promising hazard ratio for death.
- Despite some adverse events being more frequent with neoadjuvant therapy, the overall survival benefits were not significantly established, suggesting further research may be needed to confirm optimal treatment timing.
Background: Despite its importance in clinical practice, clinical guideline pathway selection and as an outcome in clinical trials, little work has been undertaken to understand the agreement between expected lung function loss and actual observed values. This is particular pertinent in view of the unexpected findings of JCOG 0802 and CALBG 140503 demonstrating no clinically meaningful difference in lung function loss between the sub-lobar resection and lobectomy arm.
Methods: We performed a retrospective analysis on preoperative and postoperative forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and diffusing capacity for carbon monoxide (DL) collated from 158 patients who underwent anatomical lung resection between January 2013 to July 2023.