Circadian profile of salivary melatonin secretion and its concentration after epileptic seizure in patients with drug-resistant epilepsy--preliminary report.

Background: The results of a few previous studies assessing melatonin concentration in epileptic patient are ambiguous. This study aimed at: (1) comparing the circadian profile of salivary melatonin excretion in epileptic patients with that in healthy subjects and with circadian frequency profile of seizures and (2) assessing the effect of epileptic seizure upon salivary melatonin concentration.

Methods: The study included thirty patients suffering from drug-resistant epilepsy aged from 22 to 45 years (mean age 37.

Neuropathy and type 1 diabetes mellitus.

Diabetic neuropathy is the most common type of neuropathies. It affects patients with both type 1 and type 2 diabetes, but it progresses more rapidly and its manifestations are more severe in type 1 diabetes. Although there has been a significant progress in the understanding of the clinical aspects of these conditions, many questions remain unanswered.