Immunohistochemical predictors in squamous cell carcinoma of the tongue and floor of the mouth.

Background: The purpose of this study was to evaluate the clinical usefulness of the immunoexpression of Ki-67, matrix metalloproteinase (MMP)-2, MMP-9, vascular endothelial growth factor (VEGF)-C, and VEGF-D in predicting follow-up treatment in patients with squamous cell carcinoma (SCC) of the tongue and floor of the mouth (FOM).

Methods: Marker expression was evaluated in surgical specimens taken from 60 patients who underwent surgery because of primary SCC without prior therapy.

Results: Strong MMP-2 expression was positively correlated with a higher risk of nodal recurrence (p = .

Endolymphatic sac tumour (ELST). Case report of a rare tumour of the temporal bone, presenting as a mass in a cerebello-pontine angle.

Endolymphatic sac tumour (ELST) is a primary low-grade, locally invasive adenocarcinoma of the endolymphatic sac, characterized by the proliferation of cuboidal cells forming a papillotubular pattern and colloid-filled cysts. Rare in the general population, it coincides significantly with the presence of von Hippel-Lindau disease. The natural history, mechanisms underlying the early symptoms, anatomical origin of ELST and optimal timing of their treatment are unknown.

HER-3 expression in HER-2-amplified breast carcinoma.

Aim Of The Study: To determine whether the expression of HER-3 influences the survival of HER-2 positive patients with breast cancer (BC).

Material And Methods: In the present work, the expression of HER-3 in a group of 35 HER-2 positive patients with BC was studied by performing immunohistochemistry (IHC) in formalin-fixed paraffin embedded tissues.

Results: Higher HER-3 status if estimated by IHC correlated significantly with older age of the patients.

[Neurothekeoma of the orbit].

Aim: The aim of this study was to present a rare benign tumour of neural origin located in the orbit.

Material And Methods: Authors describe case of six-year-old boy with tumour of the right orbit, upper eyelid and right zygomatic fossa. Medical history revealed gradually increasing in size, painless tumour.

Gene expression profiles in human ruptured and unruptured intracranial aneurysms: what is the role of inflammation?

Background And Purpose: Mechanisms underlying development and rupture of intracranial aneurysms (IA) are poorly recognized. The majority of studies on human tissue have focused on predefined pathways. We sought to analyze global gene expression patterns of ruptured IA, unruptured IA, and control vessels.

CDH1 gene promoter hypermethylation in gastric cancer: relationship to Goseki grading, microsatellite instability status, and EBV invasion.

Hypermethylation of the CDH1 promoter region seems to be the most common epigenetic mechanism in this gene silencing in gastric cancer. In this study, CDH1 promoter hypermethylation was observed in 54.8% (46/84) of the analyzed sporadic gastric carcinomas.

Assessing microvessel density in gastric carcinoma: a comparison of three markers.

Angiogenesis (AG) is necessary for cancer progression. In some cases the intensity of AG may affect the prognosis. The aim of the study was to compare the results of vessel density assessment using the stereological method and immunohistochemical reactions for three endothelial markers: CD31, CD34 and vWf.

The comparison of the agreement in determining the histological grade of uterine endometrial endometrioid carcinoma, using the three-grade FIGO classification and the two-grade system.

The objective of the investigation was to compare the degree of interobserver agreement in determining the histological grade of uterine endometrial endometrioid adenocarcinoma using the criteria proposed by the three-grade FIGO classification (1988) and the new, two-grade system proposed by Lax et al. (2000). In the FIGO system, the assessment is focused on the amount of solid, non-squamous growth pattern and the additional feature is the presence of the so-called "notable nuclear atypia" (nuclear grade), with the latter criterion not having been precisely defined.

EBV-positive gastric carcinomas in Poland.

Epstein-Barr virus plays a substantial role in numerous human neoplasms including gastric carcinoma, as proved recently. In our series EBV has been detected in five cases of forty (12.5%) gastric carcinomas.

ABL-kinase domain point mutation as a cause of imatinib (STI571) resistance in CML patient who progress to myeloid blast crisis.

Imatinib mesylate (STI571) is a major therapeutic advance for the management of chronic myeloid leukaemia (CML), however, a proportion of patients are refractory to it, particularly those in more advanced phases of CML. Different mechanisms of resistance to imatinib are suggested, including point mutations within ABL-kinase domains. A point mutation leading to substitution at the ATP binding site of ABL-kinase and insensitivity to imatinib was detected in our patient treated with imatinib, who progressed to blast crisis.