Multiscale Computational Analysis of the Effect of Taxol on Microtubule Mechanics.

Microtubules (MTs) are widely recognized as targets for cancer therapies. They are directly related to unique mechanical properties, closely dependent on MT architecture and tubulin molecular features. Taxol is known to affect tubulin interactions resulting in the stabilization of the MT lattice, and thus the hierarchical organization stability, mechanics, and function.

Understanding the contagiousness of Covid-19 strains: A geometric approach.

Protein-protein interaction occurs on surface patches with some degree of complementary geometric and chemical features. Building on this understanding, this study endeavors to characterize the spike protein of the SARS-CoV-2 virus at the morphological and geometrical levels in its Alpha, Delta, and Omicron variants. In particular, the affinity between different SARS-CoV-2 spike proteins and the ACE2 receptor present on the membrane of the human respiratory system cells is investigated.