Publications by authors named "Jabez P Fortwendel"
Article Synopsis
- Use of mixed-oil intravenous fat emulsions (MO-IFE) reduces biofilm formation by Candida albicans and lowers the rate of catheter-related bloodstream infections (CR-BSIs) compared to soybean-oil emulsions (SO-IFE).
- Research involved gene analysis of C. albicans in different IFE environments and a 5-year study on pediatric CR-BSI cases to see how IFE choice influenced Candida species distributions.
- Findings suggest that MO-IFE inhibits biofilm and hyphal growth in C. albicans through a UME6-dependent pathway, with a slight increase in non-albicans Candida infections noted, though not statistically significant.
Receipt of parenteral nutrition (PN) remains an independent risk factor for developing catheter-related bloodstream infections (CR-BSI) caused by fungi, including by the polymorphic fungus , which is notoriously adept at forming drug-resistant biofilm structures. Among a variety of macronutrients, PN solutions contain lipid emulsions to supply daily essential fats and are often delivered via central venous catheters (CVCs). Therefore, using an biofilm model system, we sought to determine whether various clinical lipid emulsions differentially impacted biofilm growth in We observed that the lipid emulsions Intralipid and Omegaven both stimulated biofilm formation during growth in minimal medium or a macronutrient PN solution.
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