Influence of surface chemistry on cytotoxicity and cellular uptake of nanocapsules in breast cancer and phagocytic cells.

The present work tests the hypothesis that stabilizers have a critical role on nanocarrier stealthiness and anticancer drug efficacy. Two different types of docetaxel (Doc)-loaded nanocapsules (NCs) stabilized with polysorbate 80 (NC(T80)) and polyvinyl alcohol (NC(PVA)) were synthesized using the emulsion solvent diffusion method. These NCs were characterized for particle mean diameter (PMD), drug content, morphology, surface composition, and degree of crystallinity.

Compression behaviour of elastically anisotropic polycrystals using energy-dispersive X-ray diffraction.

The compression behaviour of a foil of Cu3Au in a pressure medium of NaCl has been studied by energy-dispersive X-ray diffraction in a diamond-anvil cell. Evidence from stress analysis and peak broadening of the foil (the most extreme example of a non-ideal powder) throws light on the compression of powders under non-hydrostatic conditions. A complete pressure cycle, including re-pressurization after pressure release, shows that significant plastic deformation takes place which results in large deviations from a (hydrostatic) equation of state.