CXCR1 modulates SLE-associated glomerulonephritis and cardiovascular disease in MRL/lpr mice.

Objective: Patients with systemic lupus erythematosus (SLE) often develop multi-organ damages including heart and kidney complications. We sought to better define the underlying mechanisms with a focus on the chemokine receptor CXCR1.

Methods: We generated Cx3cr1-deficient MRL/lpr lupus-prone mice through backcrossing.

deficiency alters gut microbiota and ameliorates -mediated systemic autoimmunity in male mice.

NLRP12 has dual roles in shaping inflammation. We hypothesized that NLRP12 would modulate myeloid cells and T cell function to control systemic autoimmunity. Contrary to our hypothesis, the deficiency of in autoimmune-prone B6.