Publications by authors named "JR Wilson"
Tree planting schemes are implemented to achieve social, cultural, economic, and environmental goals. Various frameworks and guidelines outline good governance practices to aid the achievement of these goals. However, there is rarely sufficient monitoring and reporting of tree planting schemes for it to be possible to determine whether schemes adhere to good governance practices.
View Article and Find Full Text PDFObjective: This systematic review and meta-analysis compared minimally invasive surgery (MIS) to open surgery for treatment of spinal metastases with respect to perioperative outcomes. Few studies have systemically assessed the body of evidence on this topic.
Methods: A systematic review of EMBASE and PubMed from database inception to December 2023 was performed to identify studies comparing MIS with open surgery for the treatment of spine metastases.
Objective: Spinal cord injury (SCI) trials have historically underrepresented pediatric patients. There are limited pediatric data examining the influence of surgical timing on complications and mortality for children and adolescents who have sustained complete traumatic SCI.
Methods: The following multicenter cohort study used Trauma Quality Improvement Program data from 2010 to 2020.
Canadian Spine Society: 24th Annual Scientific Conference, Wednesday, February 28 - Saturday, March 2, Fairmont Chateau Whistler, Whistler, B.C., Canada.
Can J Surg
November 2024
Objective: To determine the association between residence in racialized neighborhoods with direct healthcare expenditure and days at home (DAH) after moderate to severe traumatic brain injury (TBI).
Summary Background Data: Differences in ethno-racial background have been associated with health outcome disparities. Much of this prior research was conducted in settings without universal healthcare coverage.
This study aims to estimate real-world clinical practice trends in time to surgery following thoracolumbar spinal cord injury (SCI) in trauma centers across North America over the last decade (2010-2020). A multi-center retrospective observational study was conducted using Trauma Quality Improvement Program data from 2010 to 2020. All surgically treated patients with thoracic and lumbar SCI were included.
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- This study analyzes the time to surgery for patients with complete traumatic cervical spinal cord injuries in North America from 2010 to 2020, using data from trauma centers and focusing on the period post-hospital arrival.
- Over the decade, the median time to spine surgery decreased by an average of 0.6 hours per year, indicating a trend towards quicker surgical intervention.
- The research involved 6855 patients and showed a significant annual reduction of 5% in time to surgery, emphasizing the improvement in response time across accredited trauma centers.
Background Context: Degenerative cervical myelopathy (DCM) is the most common cause of acquired nontraumatic spinal cord injury worldwide. Surgery is a common treatment for DCM; however, outcomes often vary across patients.
Purpose: To inform preoperative education and counseling, we performed a responder analysis to identify factors associated with treatment response.
Article Synopsis
- This study analyzes the incidence, treatment methods, and overall survival rates for chordoma patients in Ontario over 17 years (2003-2019), using data from the Ontario Cancer Registry.
- A total of 208 patients were diagnosed, with treatment trends showing an increase in radiation and chemotherapy use, while open surgery decreased, particularly for mobile spine cases.
- Overall survival probabilities at 5, 10, and 15 years post-diagnosis were 74%, 58%, and 48%, respectively, with no significant link found between survival and diagnosis year or tumor location.
Article Synopsis
- * Using health and tax data from 2007 to 2017 on 18,050 TBI patients, the research found significant income reductions—averaging CAD $7,635 in the first year and CAD $5,000 by the third year after injury—compared to uninjured individuals.
- * Additionally, 7.8% of TBI survivors became newly unemployed each year after their injury, highlighting the ongoing socioeconomic challenges faced by these individuals.
Background Context: Healthcare reimbursement is evolving towards a value-based model, entwined and emphasizing patient satisfaction. Factors associated with satisfaction after degenerative cervical myelopathy (DCM) surgery have not been previously established.
Purpose: Our primary objective was to ascertain satisfaction rates and satisfaction predictors at 3 and 12 months following surgical treatment for DCM.
Article Synopsis
- The study aims to validate "days at home" (DAH) as an outcome measure for assessing recovery after moderate to severe traumatic brain injury (TBI) using administrative health data in Ontario, Canada.
- It analyzed data from 6,340 patients between 2009 and 2021, finding that the median DAH was 70 days and 34.1% of patients died within 90 days of injury.
- The research identifies factors significantly associated with fewer DAH, including older age, higher injury severity, and greater health resource utilization before the injury.
The dispersal of organisms in the Anthropocene has been profoundly altered by human activities, with far-reaching consequences for humans, biodiversity, and ecosystems. Managing such dispersal effectively is critical to achieve the 2030 targets of the Kunming-Montreal Global Biodiversity Framework. Here, we bring together insights from invasion science, movement ecology, and conservation biology, and extend a widely used classification framework for the introduction pathways of alien species to encompass other forms of dispersal.
View Article and Find Full Text PDFSeveral false positive low serum cryptococcal antigen (SCrAg) reports by lateral flow assay (LFA) were identified in late 2016 at our tertiary care hospital. After the recall and correction of the problem in the reagent, we studied the significance of SCrAg LFA ≤ 1:10 from January 2017 to October 2023. Of 20 patients with 31 samples of SCrAg LFA ≤ 1:10, 14 patients (70%) were classified as true positives, four (20%) were indeterminate, and only two (10%) patients were false positives.
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- Degenerative cervical myelopathy (DCM) affects about 2% of adults, and there is a lack of standardized outcomes in clinical research, leading to inconsistencies in study results; creating a standardized minimum data set could enhance comparability.* -
- The study used a modified Delphi method to develop a core outcome set (COS), core data elements (CDEs), and a core measurement set (CMS) for DCM research, with input from an international stakeholder group.* -
- In total, 28 outcomes were identified across 6 key domains, culminating in a structured data set that can be utilized in future clinical trials to ensure consistency and improve measurement accuracy in DCM research.*
Article Synopsis
- The study examines six cases of perioperative spinal cord injury (SCI) that occurred during complex adult deformity surgeries, noting their causes, treatments, and outcomes.
- Out of 272 patients from the Scoli-RISK-1 cohort study, 2.2% experienced SCI, with cases occurring both during and after surgery.
- The findings highlight the importance of close postoperative monitoring and timely intervention to prevent lasting neurological damage.
Importance: Identifying disparities in health outcomes related to modifiable patient factors can improve patient care.
Objective: To compare likelihood of withdrawal of life-supporting treatment (WLST) and mortality in patients with complete cervical spinal cord injury (SCI) with different types of insurance.
Design, Setting, And Participants: This retrospective cohort study collected data between 2013 and 2020 from 498 trauma centers participating in the Trauma Quality Improvement Program.
Article Synopsis
- A 33-year-old woman was found unresponsive after taking what she believed were Valium pills, but tests revealed she had ingested sulfonylureas, leading to severe hypoglycemia.
- Her blood glucose levels were critically low (15-18 mg/dL), and treatment required intravenous dextrose to stabilize her condition.
- The case highlights the potential for sulfonylureas to cause hypoglycemia and the importance of recognizing drug substitution or contamination in patients suspected of using illicit drugs.
Terrestrial and ocean ecosystems are increasingly under threat from an array of anthropogenic pressures. And while threats mount, how people view and value nature is changing. In the United States (U.
View Article and Find Full Text PDFBackground: Healthcare inequities for patients with traumatic brain injury (TBI) represent a major priority area for trauma quality improvement. We hypothesized a relationship between health insurance status and timing of withdrawal of life sustaining treatment (WLST) for adults with severe TBI.
Methods: This multicenter retrospective observational cohort study utilized data collected between 2017 and 2020.
Importance: Spinal cord injury (SCI) causes drastic changes to an individual's physical health that may be associated with the ability to work.
Objective: To estimate the association of SCI with individual earnings and employment status using national administrative health databases linked to income tax data.
Design, Setting, And Participants: This was a retrospective, national, population-based cohort study of adults who were hospitalized with cervical SCI in Canada between January 2005 and December 2017.
Background: Histone ubiquitination modification is emerging as a critical epigenetic mechanism involved in a range of biological processes. In vitro reconstitution of ubiquitinated nucleosomes is pivotal for elucidating the influence of histone ubiquitination on chromatin dynamics.
Results: In this study, we introduce a Non-Denatured Histone Octamer Ubiquitylation (NDHOU) approach for generating ubiquitin or ubiquitin-like modified histone octamers.
Article Synopsis
- The IPBES invasive alien species assessment is the first comprehensive global review focusing on the threats posed by invasive species to biodiversity and human wellbeing, synthesizing over 13,000 scientific and local knowledge sources.
- It reveals significant and escalating threats from invasive alien species and outlines practical management strategies for addressing these challenges.
- The assessment has garnered support from 143 member states, urging immediate action against biological invasions to protect ecosystems and communities worldwide.
Background: Dexamethasone (DEX) has been shown to reduce pain and postoperative nausea and vomiting for patients undergoing elective total joint arthroplasty (TJA). We investigated the impact of DEX on glycemic control and outcomes in patients with type 2 diabetes mellitus undergoing elective primary TJA.
Methods: All patients with type 2 diabetes mellitus undergoing primary elective TJA between January 2016 and December 2021 at 4 sites within 1 hospital system were identified.
Background: Spinal metastases are a significant complication of advanced cancer. In this study, we assess temporal trends in the incidence and timing of spinal metastases and examine underlying patient demographics and primary cancer associations.
Methods: In this population-based retrospective cohort study, health data from 2007 to 2019 in Ontario, Canada were analyzed ( = 37, 375 patients identified with spine metastases).