Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution.

Severe COVID-19 is accompanied by rampant immune dysregulation in the lung and periphery, with immune cells of both compartments contributing to systemic distress. The extent to which immune cells of the lung and blood enter similar or distinct pathological states during severe disease remains unknown. Here, we leveraged 96 publicly available single-cell RNA sequencing datasets to elucidate common and compartment-specific features of severe to critical COVID-19 at the levels of transcript expression, biological pathways, and ligand-receptor signaling networks.

The chemistry of Norwegian groundwaters: III. The distribution of trace elements in 476 crystalline bedrock groundwaters, as analysed by ICP-MS techniques.

Four hundred and seventy-six groundwater samples from boreholes in Norwegian crystalline bedrock have been analysed by ICP-MS techniques. The results for 53 trace elements are presented as cumulative frequency distribution diagrams and are compared with relevant international drinking water norms. A range of trace elements appear to be enriched in granitic waters and depleted in anorthositic waters which is to be expected as generally granitic rocks are enriched in trace elements above those in anorthosites.

The chemistry of Norwegian groundwaters: II. The chemistry of 72 groundwaters from Quaternary sedimentary aquifers.

Seventy-two samples of groundwater derived from Norwegian Quaternary (largely glaciofluvial or glacial) aquifers were analysed for a wide range of major and minor hydrochemical parameters. The waters exhibit a relatively uncomplex evolution from Na-Cl dominated, immature waters (which reflect marine salts in precipitation) to Ca-HCO3 dominated waters via calcite dissolution. The median pH of these waters is 7.

The chemistry of Norwegian groundwaters: I. The distribution of radon, major and minor elements in 1604 crystalline bedrock groundwaters.

A quality-controlled hydrogeochemical dataset of 1604 groundwater samples from Norwegian crystalline bedrock aquifers has been obtained and subject to analyses of radon (scintillation counting), major and minor elements (ion chromatography and ICP-AES), pH and alkalinity. Cumulative probability curves may be constructed to assess the risk of given parameters violating drinking water norms. Parameters such as radon and fluoride show clear lithological correlation, occurring at high concentrations in granites and low concentrations in anorthosites.