Team-Based Approach to Successful Annual Wellness Visits.

Objective: The purpose of this study was to implement a 2-phase approach to rapidly increase the number of annual wellness visits (AWVs) and build a sustainable model at 3 study units (Mayo Clinic in Rochester, Minnesota, and clinics in 2 regions of Mayo Clinic Health System), which collectively serve approximately 80 000 patients who qualify for an AWV annually.

Methods: In the rapid improvement phase, beginning in July 2022, goals at the facilities were reoriented to prioritize AWVs, educate staff on existing AWV resources, and create low-effort workflows so that AWVs could be incorporated into existing patient appointments. Staff at all 3 study units worked independently and iterated quickly.

Finding landmarks - An investigation of viewing behavior during spatial navigation in VR using a graph-theoretical analysis approach.

Vision provides the most important sensory information for spatial navigation. Recent technical advances allow new options to conduct more naturalistic experiments in virtual reality (VR) while additionally gathering data of the viewing behavior with eye tracking investigations. Here, we propose a method that allows one to quantify characteristics of visual behavior by using graph-theoretical measures to abstract eye tracking data recorded in a 3D virtual urban environment.

Bioavailability of a new oral methoxsalen formulation. A serum concentration and photosensitivity response study.

A new encapsulated liquid preparation of methoxsalen (soft gelatin capsule) was compared with the currently marketed hard gelatin capsule form and with an oral solution of methoxsalen in a random crossover design. Serial serum samples were collected from 25 healthy adult subjects and assayed by a high-performance liquid chromatography technique. Additionally, photosensitivity was determined by serial testing in 12 subjects.

Metabolite of (-)-trans-delta 8-tetrahydrocannabinol: identification and synthesis.

The major metabolite of (-)-trans-Delta(8)-tetrahydrocannabinol observed in vivo and formed by hepatic microsomes in vitro is 11-hydroxy-trans-Delta(8)-tetrahydrocannabinol. The metabolite was identified spectroscopically and was synthesized from trans-Delta(8)-tetrahydrocannabinol. In tests with rats, the metabolite produced behavioral effects similar to those imparted by Delta(8)- and Delta(9)-tetrahydrocannabinol.