Women throughout the ages have preferred to be delivered with their trunks vertical and most delivery positions illustrated in historical texts show birth in an upright posture with abducted thighs. A consumer attitude study in our hospital showed that patients have considerable interest in alternative birth positions. Squatting has been advocated to prevent caval compression, increase the diameter of the pelvic outlet and, perhaps with least justification, to enlist the force of gravity and thereby facilitate maternal expulsive effort.
View Article and Find Full Text PDFFolia Microbiol (Praha)
December 1989
The effect of various physico-chemical factors on production of intra- and extracellular phospholipase A1 by Salmonella newport was investigated. Maximum intracellular enzyme levels were observed when cells were grown in brain heart infusion broth, after 12 h of incubation at 37 degrees C. Highest level of extracellular phospholipase A1, however, was seen in synthetic medium (pH 7.
View Article and Find Full Text PDFThe dihydropteridine reductase (DHPR) inhibitory potencies of some 4-phenyltetrahydropyridines, 4-phenylpiperidines, and 4-phenylpyridines, are analyzed in relation to their physico-chemical and molecular properties. They are found to have significant correlation with Hammett constant sigma and the van der Waals volume Vw. The correlation is linear with sigma and parabolic with Vw.
View Article and Find Full Text PDFA quantitative structure-activity relationship study has been made of some 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. The HMG-CoA reductase inhibition activities of mevinolin analogs and 6-substituted 4-hydroxypyran-2 ones have been mostly found to be significantly correlated with the molecular size of substituents. In one case, however, the inhibition potency was found to be related to the hydrophobicity of molecules.
View Article and Find Full Text PDFRes Commun Chem Pathol Pharmacol
August 1988
The structure-activity relationship of papaverine analogs, the inhibitors of adenosine cyclic 3', 5'-monophosphate (c-AMP) phosphodiesterase, is discussed. The enzyme inhibition activity of these compounds are found to be dominantly controlled by hydrophobicity and steric factors. A significant quantitative correlation has been obtained between the inhibition activity and the van der Waals volume.
View Article and Find Full Text PDFSixteen ovarian cysts, including one borderline ovarian malignancy, and ten trichomonal vaginal discharges but no cases of cervical incompetence or ectopic pregnancy had been detected at booking vaginal examination in 11,622 consecutive antenatal case records abstracted retrospectively. In an attitude survey of pregnant women 77% believed that vaginal examination was reassuring, 55% found it unpleasant, and 18% thought it could cause miscarriage. This, and a review of the literature, suggests that routine vaginal examination if ultrasound is planned has few advantages beyond the taking of a cervical smear.
View Article and Find Full Text PDFIndian J Physiol Pharmacol
August 1984
In an attempt to minimize the gastric ulcerogenicity of 6-methoxyindan-1-acetic acid and 5,6-dimethoxyindan-1-acetic acid exhibiting high anti-inflammatory activity, we synthesized their esters, amides and nitrile derivatives. It was found that the anti-inflammatory activity of ethyl esters were almost equal to those of parent acids and phenylbutazone while other derivatives were less potent. Those ethyl esters were also found to be much less ulcerogenic than phenylbutazone.
View Article and Find Full Text PDFIndian J Physiol Pharmacol
February 1983
The anti-inflammatory activity of 6-methoxyindan-1-acetic acid (1a) and 5,6-dimethoxyindan-1-acetic acid (1b) was evaluated in various acute, subacute and chronic models of inflammation. The results of these studies suggest that they have equal or slightly more anti-inflammatory activity than phenylbutazone, a standard anti-inflammatory drug. Of the two compounds, 5,6-dimethoxyindan-l-acetic acid appeared to be slightly more active than 6-methoxyindan-l-acetic acid.
View Article and Find Full Text PDFSerum albumin, ceruloplasmin, transferrin and haptoglobin were studied in 50 patients with both toxic and non-toxic forms of goitre. Albumin was monomorphic in all cases and its amount was substantially lower than normal in two patients. Ceruloplasmin was both qualitatively and quantitatively normal in all patients.
View Article and Find Full Text PDFNineteen fungi were isolated from different soil samples on the basis of clear zones formed on Rose Bengal Cellulose agar medium. In shake flasks th isolate K1 gave 12.1 units/ml of CMCase activity.
View Article and Find Full Text PDFIndian J Physiol Pharmacol
June 1981
A series of indan-1 acids were synthesized and screened for anti-inflammatory activity. All the reported compounds showed varying degrees of anti-inflammatory activity in carrageenin-induced paw oedema test. They also exhibited appreciable antipyretic and analgesic activity in various animal test models.
View Article and Find Full Text PDFSterility in males and females was observed in the resulting adults when 3--4-day-old pupae of solanaceous hadda, Epilachna vigintioctopunctata F. were exposed to gamma radiation doses of 2000 rad and 2500 rad. However, at 2500 rad longevity of treated insects was adversely affected.
View Article and Find Full Text PDFCellulase produced by Trichoderma viride acted on carboxymethyl cellulose with a Km of 4.9 g substrate per litre, showing a pH optimum at 4.5 and a temperature optimum at 55 degrees C.
View Article and Find Full Text PDFMalabsorption tests were studied in 52 patients with multiple sclerosis. The stools were examined microscopically for fat and undigested meat fibers and were found to be abnormal in 41.6 and 40.
View Article and Find Full Text PDFJejunal mucosa from 7 patients with amyotrophic lateral sclerosis (A.L.S.
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