Publications by authors named "JESPERSEN C"
Objective: We aimed to examine a) the policies of national and international clinical trial registries regarding observational studies; b) the time-trends of observational study registration; c) the published arguments for and against observational study registration.
Study Design And Setting: Scoping review of registry practices and published arguments. We searched the websites and databases of all 19 members of the World Health Organization's Registry Network to identify policies relating to observational studies and the number of observational studies registered annually from the beginning of the registries to 2022.
Article Synopsis
- PMS and PMDD are common conditions affecting women before menstruation, with PMDD being a more severe form, and SSRIs are often used for treatment.
- A systematic review was conducted to evaluate the benefits and risks of SSRIs in treating these syndromes based on randomized controlled trials.
- The review updated data collection methods from a 2013 study, analyzing treatment effectiveness and the potential for adverse effects associated with SSRIs.
Background: Multisystem functional somatic disorder is characterized by specific patterns of persistent physical symptoms with a complex biopsychosocial etiology. The disorder can lead to disability and personal suffering. Current treatment options require specialized settings, therefore patients often wait a long time to receive specific treatment.
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- - The study examined the effectiveness of cardiac resynchronization therapy (CRT) among immigrants and non-immigrants in Denmark, focusing on heart failure-related hospitalizations and overall mortality from 2000 to 2017.
- - Results showed that both groups experienced similar improvements in hospitalizations after CRT, but there was no significant difference in five-year mortality rates overall, although Middle Eastern immigrants had higher mortality compared to non-immigrants.
- - The majority of deaths in both groups were due to cardiovascular issues, indicating that while CRT was effective for both populations, certain demographics may face increased risks post-therapy.
Article Synopsis
- The study investigates the relationship between Brugada syndrome (BrS) diagnosis and the development of new-onset depression or anxiety, as well as all-cause mortality among patients over a follow-up period of up to 5 years.
- Out of 223 patients identified with BrS, 15.7% developed new-onset depression or anxiety, with symptomatic patients showing a higher incidence compared to asymptomatic ones.
- The findings suggest that factors like symptomatic disease presentation and older age are significantly linked to an increased risk of developing mental health issues in BrS patients, although overall mortality rates were low.
Article Synopsis
- About one-third of patients diagnosed with Brugada syndrome (BrS) were treated with nonrecommended medications, with no significant change in prescription patterns observed post-diagnosis.
- Female patients, those with psychiatric diseases, and those with prior use of nonrecommended drugs were more likely to use these medications after diagnosis.
- No significant associations were found between nonrecommended drug use and outcomes like appropriate implantable cardioverter defibrillator therapy, mortality, or arrhythmic events during follow-up.
Multimicrophone array techniques offer crucial insight into bat echolocation, yet they severely undersample the environments bats operate in as they are limited in geographic placement and mobility. UAVs are excellent candidates to greatly increase the environments in which such arrays can be deployed, but the impact of UAV noise on recording quality and the UAV's behavioral impact on the bats may affect usability. We developed a UAV-borne multimicrophone setup capable of recording bat echolocation across diverse environments.
View Article and Find Full Text PDFFriedreich ataxia (FRDA) is a recessive neurodegenerative disease characterized by progressive ataxia, dyscoordination, and loss of vision. The variable length of the pathogenic GAA triplet repeat expansion in the gene in part explains the interindividual variability in the severity of disease. The GAA repeat expansion leads to epigenetic silencing of therefore, variability in properties of epigenetic effector proteins could also regulate the severity of FRDA.
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- The study aimed to evaluate the risk of developing malignant arrhythmias, specifically torsades de pointes (TdP), related to certain drugs in patients who experienced out-of-hospital cardiac arrest (OHCA).
- Researchers analyzed data from the Danish Cardiac Arrest Registry, focusing on patients 18 and older with a cardiac origin OHCA between 2001 and 2014, determining the prevalence and impact of TdP risk drug usage on patient outcomes.
- Findings showed that 37% of patients were treated with TdP risk drugs shortly before OHCA, which correlated with a decreased likelihood of experiencing a shockable rhythm and achieving return of spontaneous circulation (ROSC), although these patients tended to be older and more comorbid
We present the case of a relative of a patient with catecholaminergic polymorphic ventricular tachycardia. This relative underwent a standard (Bruce) exercise stress test (EST), which had normal results. He then underwent our modified "sprint" EST, with positive results.
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- The study investigates workforce attachment of patients with congenital long QT syndrome (cLQTS) in Denmark from 1996 to 2016, focusing on their employment status post-diagnosis.
- It finds that over 90% of cLQTS patients remained employed one year after their diagnosis, similar to a matched control group, but with a slight drop in attachment compared to the general population.
- Severe manifestations of the condition, such as aborted cardiac arrests, significantly increase the likelihood of workforce detachment within that year.
Aims: We examined if a congenital long QT syndrome (cLQTS) diagnosis and severity of cLQTS disease manifestation was associated with increased risk of depression, anxiety, and all-cause mortality.
Methods And Results: All patients with known cLQTS in Denmark were identified using nationwide registries and specialized inherited cardiac disease clinics (1994-2016) and followed for up to 3 years after their cLQTS diagnosis. Risk factors for depression, anxiety, and all-cause mortality were determined using multivariable Cox proportional-hazards regression.
Directionality is the only hearing aid technology - in addition to amplification - proven to help hearing aid users hear better in noise. Hearing aid directionality has been documented to improve speech intelligibility in multiple laboratory studies. In contrast, real-world studies have shown a disconnect between the potential of the technology and what hearing aid users experience in their daily life.
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- Brugada syndrome (BrS) is linked to mutations in a cardiac sodium channel gene, but there is limited research on the genetic factors in patients experiencing their first arrhythmic events.
- A large survey of 678 BrS patients across 14 countries identified 392 probands, with 23.5% having pathogenic or likely pathogenic (P/LP) variants, revealing differences in demographics and clinical features based on genotype.
- Results showed that patients with P/LP variants were generally younger, more often female, and had a higher incidence of family history of sudden cardiac death, suggesting a complex interplay between genetics, age, gender, and ethnicity in BrS.
Background: Active rehabilitation of Whiplash Associated Disorders (WAD) is favoured over passive modalities such as soft-collars. However, the effectiveness of soft-collar use remains unclear.
Objective: To investigate the effectiveness of soft-collar use on pain and disability in WAD.
Aims: The current knowledge of idiopathic ventricular fibrillation (IVF) is limited. We aimed to investigate the nature of IVF, including clinical assessment and later diagnosis, and risk factors of implantable cardioverter defibrillator (ICD) therapy in the follow-up period.
Methods: Between 2007 and 2019 we systematically identified all patients from Rigshospitalet, Denmark, with a resuscitated sudden cardiac arrest (SCA) with no identifiable cause.
The overall positive effects of coitus have not been estimated before. A systematic review and meta-analysis was conducted for coitus versus everything. A search was made in MEDLINE resulting in 1,121 hits.
View Article and Find Full Text PDFObjective: Studies have suggested a shared genetic aetiology between congenital long QT syndrome (LQTS) and diabetes, epilepsy and mental disorders. We investigated the prevalence of metabolic, neurological and psychiatric comorbidities in LQTS patients.
Methods: This retrospective cohort study was based on data from nationwide Danish registries, 2003-2017.
Background: There is limited information on ethnic differences between patients with Brugada syndrome (BrS) and arrhythmic events (AEs).
Objective: The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between white and Asian patients with BrS and AEs.
Methods: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter survey from Western and Asian countries, gathering 678 patients with BrS and first documented AE.
Aims: It is Class I recommendation that congenital long QT syndrome (cLQTS) patients should avoid drugs that can cause torsades de pointes (TdP). We determined use of TdP risk drugs after cLQTS diagnosis and associated risk of ventricular arrhythmia and all-cause mortality.
Methods And Results: Congenital long QT syndrome patients (1995-2015) were identified from four inherited cardiac disease clinics in Denmark.
Background: Information on young patients with Brugada syndrome (BrS) and arrhythmic events (AEs) is limited.
Objectives: The purpose of this study was to describe their characteristics and management as well as risk factors for AE recurrence.
Methods: A total of 57 patients (age ≤20 years), all with BrS and AEs, were divided into pediatric (age ≤12 years; n = 26) and adolescents (age 13 to 20 years; n = 31).
Aims: Data on predictors of time-to-first appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with Brugada Syndrome (BrS) and prophylactically implanted ICD's are scarce.
Methods And Results: SABRUS (Survey on Arrhythmic Events in BRUgada Syndrome) is an international survey on 678 BrS patients who experienced arrhythmic event (AE) including 252 patients in whom AE occurred after prophylactic ICD implantation. Analysis was performed on time-to-first appropriate ICD discharge regarding patients' characteristics.
I this case report a 37-year-old nulliparous woman was admitted for acute onset of abdominal pain. CT scan showed a homogeneous tumour related to the internal genitalia and extravasation of contrast material, but the site of bleeding was not identifiable. Ultrasonography revealed leiomyoma and haemoperitoneum, and emergency laparoscopy was performed.
View Article and Find Full Text PDFBackground: Health anxiety (HA) is an increasing public health problem related to increased health service costs, and associated with functional somatic symptoms (FSS) and considerable personal suffering. Abnormal bodily experiences which may resemble HA and FSS are common in psychotic disorders, but a potential link between HA and psychosis vulnerability in childhood is largely unexplored. The current study estimates the association between subclinical psychotic experiences (PE) and HA and FSS in a general population cohort of preadolescents.
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