Retraction: Aerobic exercise reverses the NF-κB/NLRP3 inflammasome/5-HT pathway by upregulating irisin to alleviate post-stroke depression.

[This retracts the article DOI: 10.21037/atm-22-5443.].

Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging.

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice.

Individual Assembly of Radical Molecules on Superconductors: Demonstrating Quantum Spin Behavior and Bistable Charge Rearrangement.

High-precision molecular manipulation techniques are used to control the distance between radical molecules on superconductors. Our results show that the molecules can host single electrons with a spin 1/2. By changing the distance between tip and sample, a quantum phase transition from the singlet to doublet ground state can be induced.

Dipicolylamine Derivatives Bearing Pyrene and Anthracene as Molecular Probes for Cu and HS.

Two dipicolylamine (DPA) derivatives with the pyrene and anthracene groups, 1-(pyren-1-yl)-N, N-bis-(pyridine-2-ylmethyl)benzylamine (L1) and 1-(anthracen-9-yl)-N, N-bis-(pyridine-2-ylmethyl)benzylamine (L2) were synthesized, characterized, and their affinitive properties for metal ions were studied. The mass spectroscopy and Job's plots showed that L1 and L2 reacted with Cu and formed complexes [Cu(L1)(solvent)] (L1-Cu) and [Cu(L2)(solvent)] (L2-Cu), respectively. Both L1 and L2 were fluorescent probes recognizing Cu via the emission quenching and further detecting HS via the emission revival.

On-Surface Synthesis and Characterization of Radical Spins in Kagome Graphene.

Flat bands in Kagome graphene might host strong electron correlations and frustrated magnetism upon electronic doping. However, the porous nature of Kagome graphene opens a semiconducting gap due to quantum confinement, preventing its fine-tuning by electrostatic gates. Here we induce zero-energy states into a semiconducting Kagome graphene by inserting π-radicals at selected locations.

Insights into the MOF-Based Classic Configuration for the Differences in Effective Dye Adsorption, Magnetic Properties, and Computational Analyses.

Two 3D/2D anionic metal-organic frameworks (MOFs), [Cu(HL)] () and [Mn(L)(DMF)] ( (DMF = ,-dimethylformamide), were synthesized by the solvothermal reaction of metal salts and 5'-(4-carboxyphenyl)-2',4',6'-triethyl-[1,1':3',1″-terphenyl]-4,4″-dicarboxylic acid (HL). Single-crystal X-ray diffraction analyses revealed that complex shows three-dimensional (3D) frameworks with a (3,6)-connected 3-fold interpenetrated topology with the Schläfli symbols of {4.6}{4.

Fucoidan Attenuates Cardiac Remodeling by Inhibiting Galectin-3 Secretion, Fibrosis, and Inflammation in a Mouse Model of Pressure Overload.

Background/objectives: Fucoidan, a sulfated polysaccharide derived from marine algae, is known for its antioxidant and immunomodulatory properties. Galectin-3 (Gal-3), a protein associated with cardiovascular fibrosis, has been identified as a potential therapeutic target in cardiac remodeling. This study aimed to evaluate whether fucoidan could inhibit Gal-3 activity and mitigate cardiac remodeling in a mouse model of pressure overload-induced cardiac hypertrophy.

[Study on the Production of Anti-D and Anti-E Mixed Antibodies by Alloimmunization in RhD Variant Type33 Recipients].

Objective: To investigate the cause of the production of anti-D and anti-E mixed antibody in an RhD positive patient.

Methods: The ABO/Rh blood group typing and irregular antibody specificity were identified by conventional serological methods, the gene exon 1-10 and heterozygous analysis were performed by sequence-specific primer polymerase chain reaction (PCR-SSP), and the whole exon sequence was analyzed by first-generation sequencing.

Results: The patient's Rh blood group was weak D Type33, with the allele was , the patients was found to be heterozygous, with an Rh typing of Ccee, and the patient had developed anti-D combined with anti-E mixed antibodies.

[Wild boar resource and its conflict with human in Zhejiang Province, East China].

Human-wildlife conflict is one of the important research topics in biodiversity and conservation. Understanding the status of wildlife resources and its conflict with human could promote the sustainable protection and management of wildlife. Wild boar () is one of the most widely distributed ungulates in the world, with an increasing population and recently rising levels of conflict with human.

Spin Excitations of High Spin Iron(II) in Metal-Organic Chains on Metal and Superconductor.

Many-body interactions in metal-organic frameworks (MOFs) are fundamental for emergent quantum physics. Unlike their solution counterpart, magnetization at surfaces in low-dimensional analogues is strongly influenced by magnetic anisotropy (MA) induced by the substrate and still not well understood. Here, on-surface coordination chemistry is used to synthesize on Ag(111) and superconducting Pb(111) an iron-based spin chain by using pyrene-4,5,9,10-tetraone (PTO) precursors as ligands.

The pleiotropic effects of statins: a comprehensive exploration of neurovascular unit modulation and blood-brain barrier protection.

The blood-brain barrier (BBB) is the most central component of the neurovascular unit (NVU) and is crucial for the maintenance of the internal environment of the central nervous system and the regulation of homeostasis. A multitude of neuroprotective agents have been developed to exert neuroprotective effects and improve the prognosis of patients with ischemic stroke. These agents have been designed to maintain integrity and promote BBB repair.

Dynamic phase transitions dictate the size effect and activity of supported gold catalysts.

The landmark discovery of gold catalysts has aroused substantial interest in heterogeneous catalysis, yet the catalytic mechanism remains elusive. For carbon monoxide oxidation on gold nanoparticles (NPs) supported on ceria surfaces, it is widely believed that carbon monoxide adsorbs on the gold particles, while the reaction occurs at the gold/ceria interface. Here, we have investigated the dynamic changes of supported gold NPs with various sizes in a carbon monoxide oxidation atmosphere using deep potential molecular dynamics simulations.

Pericardial-Esophageal Fistula After Combined Ablation and Left Atrial Appendage Occlusion Procedure for Atrial Fibrillation.

Pericardial-esophageal fistula is a rare complication after radiofrequency ablation for atrial fibrillation. A 52-year-old man developed pneumopericardium, which was revealed by echocardiogram and computed tomography, after a combined ablation and left atrial appendage occlusion procedure for atrial fibrillation. He was diagnosed with a pericardial-esophageal fistula and underwent surgical pericardial and mediastinal drainage tube placement.

Advancing oral cancer care: Insights from Tongluo Jiedu prescription.

This editorial highlights the study which investigated the potential of traditional Chinese medicine (TCM) as an adjunctive therapy in oral cancer management. The study included 80 patients with oral cancer to evaluate the effects of the Tongluo Jiedu prescription on inflammatory stress markers, peripheral blood T-cell subsets, and overall immune function. The results indicated that Tongluo Jiedu substantially enhances immune function and reduces oxidative stress, thereby aiding in patient recovery and potentially minimizing treatment-related complications.

Teneligliptin mitigates diabetic cardiomyopathy through inflammasome inhibition: Insights from experimental studies.

This article provides commentary on the article by Zhang . In this original research, Zhang investigated the therapeutic potential of teneligliptin for diabetic cardiomyopathy (DCM), which was mediated by targeting the NOD-like receptor protein 3 (NLRP3) inflammasome. Through the use of both and models, the study demonstrated that teneligliptin alleviates cardiac hypertrophy, reduces myocardial injury, and mitigates the inflammatory responses associated with DCM.

Photochromic Dysprosium Single-Molecule Magnet Featuring Reversible Redox Transformation of Polyoxomolybdate Moiety.

A photochromic dysprosium-based single-molecule magnet [Dy(CyPhPO)(HO)](PMoO) ⋅ 3CyPhPO⋅HO (1-Dy) is synthesized via cocrystal engineering of a polyoxomolybdate (POMo) anion and an Ising-type cation with pseudo pentagonal bipyramidal geometry. Upon ultraviolet irradiation, Mo-to-Mo single-electron photoreduction occurs in the POMo moiety, resulting in significant changes of optical and magnetic properties. The emergence of intervalence charge-transfer transitions in heteropoly blue state 1-Dy* facilitates photothermal conversion in near-infrared region.

Focal liver lesions: multiparametric microvasculature characterization via super-resolution ultrasound imaging.

Background: Noninvasive and functional imaging of the focal liver lesion (FLL) vasculature at microscopic scales is clinically challenging. We investigated the feasibility of using super-resolution ultrasound (SR-US) imaging for visualizing and quantifying the microvasculature of intraparenchymal FLLs.

Methods: Patients with FLLs between June 2022 and February 2023 were prospectively screened.

Gelation melioration of clam Meretrix meretrix surimi based on the interactions with different plant/animal proteins.

The effects and mechanisms of four exogenous proteins, soy protein isolate (SPI), pea protein isolate (PPI), egg white protein (EWP), and whey protein isolate (WPI), on the gelation of Meretrix meretrix (MM) surimi were investigated. The exogenous protein addition significantly increased the G* of samples to 1.36-1.

Epileptic Seizures from Atrio-Esophageal Fistula: A Deadly Outcome of Atrial Fibrillation Ablation.

We report a case highlighting the global prevalence of atrial fibrillation (Afib) and the increased use of ablation therapy, underscoring the importance of understanding its complications, especially atrio-esophageal fistula (AEF), a rare but potentially fatal outcome. This case involves a 38-year-old male who underwent radiofrequency ablation for Afib and was subsequently hospitalized with abrupt left-sided weakness. Initially presumed to be a transient ischemic attack (TIA), his condition progressed to seizures and reduced consciousness.

Kinase-Bench: Comprehensive Benchmarking Tools and Guidance for Achieving Selectivity in Kinase Drug Discovery.

Developing selective kinase inhibitors remains a formidable challenge in drug discovery because of the highly conserved structural information on adenosine triphosphate (ATP) binding sites across the kinase family. Tailoring docking protocols to identify promising kinase inhibitor candidates for optimization has long been a substantial obstacle to drug discovery. Therefore, we introduced "Kinase-Bench," a pioneering benchmark suite designed for an advanced virtual screen, to improve the selectivity and efficacy of kinase inhibitors.

Boosting Enzyme-like Activities Atomization of Cerium for Tumor Microenvironment-Responsive Cascade Therapy.

Nanozyme catalytic therapeutic efficacy is limited by the finite enzyme activity and specificity. In this work, nitrogen-doped carbon loaded with a cerium single-atom nanozyme (Ce SAs@NC) is synthesized, exhibiting tumor specificity and excellent multiple enzyme-like activities. Compared with nitrogen-doped carbon loaded with CeO nanoparticles, Ce SAs@NC shows excellent peroxidase-like and catalase-like activity.

[Impact of ambient air pollution on hospital visits for mental and behavioral disorders among residents in an industrial area in Henan Province from 2016 to 2021].

To explore the impact of air pollution on hospital visits for mental and behavioral disorders among residents in an industrial area in Henan Province from 2016 to 2021. Daily outpatient visits data for mental and behavioral disorders, as well as air pollutants and meteorological data during the same period, were collected from Angang General Hospital in Angang Industrial Zone at Anyang City between January 2016 and December 2021. A generalized additive model was used for time-series analysis to examine the relationship between daily average concentrations of nitrogen dioxide (NO), sulfur dioxide (SO), fine particulate matter (PM), inhalable particulate matter (PM), carbon monoxide (CO), and ozone (O) with a lag of 0 to 7 days on the number of visits for mental and behavioral disorders among residents.

Dietary patterns and risk of multiple cancers: umbrella review of meta-analyses of prospective cohort studies.

Background: Numerous prospective cohort studies have investigated the influence of dietary patterns on the risks of various cancers, although the findings differed.

Objectives: To evaluate the associations of dietary patterns with risks of various cancers and assess the strength and validity of the evidence.

Methods: Relevant articles were retrieved from the PubMed, EMBASE, Web of Science, and Cochrane library databases from inception to February 22, 2024.