Adjuvant chemotherapy in the management of primary malignant melanoma.

In a prospective randomized study, the effect of chemotherapy (either systemic or combined intraarterial and systemic) was studied in 117 patients undergoing a curative resection of Clark's level III, IV or V malignant melanoma. Systemic chemotherapy was started one month after surgery one week courses with an I.V.

[Treatment of malignant melanoma (author's transl)].

According to Clark there are three different types of melanoma: malignant melanoma which develops from the floor of a precancerous melanosis, the extensive superficial melanoma and nodular malignant melanoma. Therapeutically, surgery occupies the first place. Chemotherapeutically the combination of 3 or 4 different substances has given favorable results.