Methemoglobin aggregation is modulated by the anti-sickling drug voxelotor.

Unlabelled: Sickle cell disease is caused by a mutation in the beta subunit of hemoglobin (HbSS) that drives Hb fiber formation when the protein is in the deoxygenated (tense, T) state. The drug voxelotor was recently approved to treat sickle cell disease by preventing HbSS fiber formation. Voxelotor acts as an allosteric inhibitor of polymerization by maintaining the HbSS protein in the relaxed (R) conformation, limiting polymerization of T-state fibers.

USE-DILUTION TEST AND NEWCASTLE DISEASE VIRUS.

The use-dilution test for evaluating the effectiveness of disinfectants against bacteria was modified to determine the effectiveness of disinfectants against a group of viruses. Modifications were kept to a minimum to retain the general principles of the test and thereby retain the test's familiarity among testing laboratory personnel. Modifications included the use of a standard allantoic fluid suspension of Newcastle disease virus instead of a standard bacterial culture.

Utilization of carbohydrates and polyhydric alcohols by Mycobacterium tuberculosis.

Sweeney, Edward E. (University of California, Los Angeles) and Gregory J. Jann.