Publications by authors named "J-T Gan"
Article Synopsis
- Echocardiographic strain imaging is important for assessing heart function, and deep learning (DL) algorithms can automate its interpretation.
- An automated DL-based algorithm for measuring left ventricular strain was trained and validated using datasets from various studies, showing high accuracy compared to manual measurements.
- The study concluded that DL algorithms can interpret echocardiographic strain images effectively, potentially improving accessibility to cardiac assessments.
Introduction: An association between functional dyspepsia (FD) and wheat-containing foods has been reported in observational studies; however, an adaptive response has not been demonstrated. We examined whether antigens present in wheat could provoke a response from FD duodenal lymphocytes.
Methods: Lamina propria mononuclear cells (LPMCs) were isolated from duodenal biopsies from 50 patients with FD and 23 controls.
Background: Despite significantly reduced acute myocardial infarction (MI) mortality in recent years, ischemic heart failure continues to escalate. Therapeutic interventions effectively reversing pathological remodeling are an urgent unmet medical need. We recently demonstrated that AdipoR1 (APN [adiponectin] receptor 1) phosphorylation by GRK2 (G-protein-coupled receptor kinase 2) contributes to maladaptive remodeling in the ischemic heart.
View Article and Find Full Text PDFDysregulated adenosine-to-inosine (A-to-I) RNA editing is implicated in various cancers. However, no available RNA editing inhibitors have so far been developed to inhibit cancer-associated RNA editing events. Here, we decipher the RNA secondary structure of antizyme inhibitor 1 (AZIN1), one of the best-studied A-to-I editing targets in cancer, by locating its editing site complementary sequence (ECS) at the 3' end of exon 12.
View Article and Find Full Text PDFPurpose: A validated questionnaire assessing diabetic retinopathy (DR)- and diabetic macular edema (DME)-related knowledge (K) and attitudes (A) is lacking. We developed and validated the Diabetic Retinopathy Knowledge and Attitudes (DRKA) questionnaire and explored the association between K and A and the self-reported difficulty accessing DR-related information (hereafter referred to as Access).
Methods: In this mixed-methods study, eight focus groups with 36 people with DR or DME (mean age, 60.
Article Synopsis
- Researchers studied how inflammation in the body might be connected to heart issues in people who have heart failure with preserved ejection fraction (HFpEF).
- They looked at 228 patients and measured 248 proteins in their blood to see which ones were linked to inflammation and heart problems.
- They found that more health issues (comorbidities) led to more inflammation, which caused worse heart function, showing that inflammation plays a big role in the heart problems of these patients.
Purpose: To determine the rates and develop an initial risk prediction model for nonadherence to post screening ophthalmic referral (PSOR) in type 2 diabetes mellitus (T2DM) patients attending a national diabetic retinopathy screening program in Singapore.
Methods: Data from 2387 patients with T2DM (mean [standard deviation] age: 66.5 [11] years; 52.
Background: The role of right ventricular (RV) diastolic stiffness in pulmonary arterial hypertension (PAH) is not well established. Therefore, we investigated the presence and possible underlying mechanisms of RV diastolic stiffness in PAH patients.
Methods And Results: Single-beat RV pressure-volume analyses were performed in 21 PAH patients and 7 control subjects to study RV diastolic stiffness.