Context: Growth of short children in puberty is limited by the effect of estrogen on epiphyseal fusion.
Objectives: To compare: 1) the efficacy and safety of aromatase inhibitors (AIs) vs GH vs AI/GH on increasing adult height potential in pubertal boys with severe idiopathic short stature (ISS); and 2) differences in body composition among groups.
Design: Randomized three-arm open-label comparator.