Publications by authors named "J-M Howes"
The dynamic ribosome-translocon complex, which resides at the endoplasmic reticulum (ER) membrane, produces a major fraction of the human proteome. It governs the synthesis, translocation, membrane insertion, N-glycosylation, folding and disulfide-bond formation of nascent proteins. Although individual components of this machinery have been studied at high resolution in isolation, insights into their interplay in the native membrane remain limited.
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- Ibrutinib, a drug targeting Bruton's tyrosine kinase, shows promise when combined with bendamustine and rituximab for older patients with untreated mantle-cell lymphoma.
- In a study of 523 patients aged 65 and older, those receiving ibrutinib experienced significantly longer progression-free survival (80.6 months) compared to the placebo group (52.9 months).
- While overall survival rates were similar, the incidence of serious side effects was slightly higher in the ibrutinib group, but the treatment's safety aligned with established profiles of the drugs involved.